4-Nitro-3-phenylphenol has both androgenic and anti-androgenic-like effects in rats

The Journal of Reproduction and Development
Jiratthiya TrisomboonKazuyoshi Taya

Abstract

To investigate the effect of endocrine disruption of 4-nitro-3-phenylphenol (PNMPP) on immature male Wistar-Imamichi rats, the rat pituitary was exposed to PNMPP (10(-5)-10(-9) M) for 24 h with or without gonadotropin-releasing hormone (GnRH) in experiment I. In addition, the Leydig cells (10(-5)-10(-9) M) were exposed to PNMPP for 24 h with or without human chronic gonadotropin (hCG) in experiment II. Our results showed that the PNMPP at 10(-5)-10(-7) M suppressed follicle-stimulating hormone (FSH) and luteinizing hormone (LH) productions from GnRH-stimulated pituitary cells. At the same time, PNMPP 10(-5)-10(-7) M induced an increase in testosterone production from the Leydig cells treated with or without hCG. Based on our results, it can be concluded that that PNMPP might have both androgen agonist action by decreasing FSH and LH production in the pituitary and anti-androgenic action by increasing testosterone production in the Leydig cell.

References

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Jan 23, 2004·Biology of Reproduction·Chie FurutaKazuyoshi Taya
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Jul 7, 2007·The Journal of Reproduction and Development·Hiromi IzawaMasaru Sagai
Apr 29, 2008·Toxicology and Applied Pharmacology·Chie FurutaKazuyoshi Taya
May 8, 2008·Bioscience, Biotechnology, and Biochemistry·Hiromi IzawaMasaru Sagai
Sep 23, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Tomoko KomatsuKen Takeda
Aug 7, 2012·Inhalation Toxicology·ChunMei LiKazuyoshi Taya

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Citations

Feb 13, 2020·Current Medical Research and Opinion·Ilaria SoaveDonatella Caserta
Aug 9, 2020·Beilstein Journal of Organic Chemistry·Haruyasu AsaharaNagatoshi Nishiwaki

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