4-(Phenylsulfanyl)butan-2-One Suppresses Melanin Synthesis and Melanosome Maturation In Vitro and In Vivo

International Journal of Molecular Sciences
Shing-Yi Sean WuZhi-Hong Wen

Abstract

In this study, we screened compounds with skin whitening properties and favorable safety profiles from a series of marine related natural products, which were isolated from Formosan soft coral Cladiella australis. Our results indicated that 4-(phenylsulfanyl)butan-2-one could successfully inhibit pigment generation processes in mushroom tyrosinase platform assay, probably through the suppression of tyrosinase activity to be a non-competitive inhibitor of tyrosinase. In cell-based viability examinations, it demonstrated low cytotoxicity on melanoma cells and other normal human cells. It exhibited stronger inhibitions of melanin production and tyrosinase activity than arbutin or 1-phenyl-2-thiourea (PTU). Also, we discovered that 4-(phenylsulfanyl)butan-2-one reduces the protein expressions of melanin synthesis-related proteins, including the microphthalmia-associated transcription factor (MITF), tyrosinase-related protein-1 (Trp-1), dopachrome tautomerase (DCT, Trp-2), and glycoprotein 100 (GP100). In an in vivo zebrafish model, it presented a remarkable suppression in melanogenesis after 48 h. In summary, our in vitro and in vivo biological assays showed that 4-(phenylsulfanyl)butan-2-one possesses anti-melanogenic properties t...Continue Reading

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Citations

Apr 20, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmed M NaglahAtef Kalmouch
Sep 10, 2016·Scientific Reports·Kai-Di HsuKuan-Chen Cheng
May 24, 2017·International Journal of Molecular Sciences·Chien-Jen KaoZhi-Hong Wen
Mar 23, 2017·International Journal of Biological Macromolecules·Lin GouZhi-Rong Lü
May 6, 2019·International Journal of Molecular Sciences·Yu-Mi KimYoung-Kwon Seo
Dec 1, 2017·Implant Dentistry·Chang-Kai ChenZhi-Hong Wen
May 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Claudio LuparelloMirella Vazzana
Sep 11, 2019·Archives of Dermatological Research·Shilpi Goenka, Sanford R Simon
Jul 19, 2017·International Journal of Molecular Sciences·Fatemeh BootorabiAshok Aspatwar
Jul 3, 2021·International Journal of Molecular Sciences·Kyuri KimKyung-Min Lim

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Methods Mentioned

BETA
protein assay
electrophoresis
Assay

Software Mentioned

Scion Image alpha

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