4-Week consumption of anthocyanin-rich blood orange juice does not affect LDL-cholesterol or other biomarkers of CVD risk and glycaemia compared with standard orange juice: a randomised controlled trial

The British Journal of Nutrition
Wendy J HollandsPaul A Kroon

Abstract

Elevated circulating cholesterol levels are a risk factor for CVD which is also associated with sub-optimal vascular function. There is emerging evidence that anthocyanins can cause beneficial cardio-protective effects by favourably modulating lipoprotein profiles. We compared the effects of blood orange juice which is rich in anthocyanins and blonde orange juice without anthocyanins on LDL-cholesterol and other biomarkers of CVD risk, vascular function and glycaemia. In all, forty-one participants (aged 25-84 years) with a waist circumference >94 cm (men) and >80 cm (women) completed a randomised, open label, two-arm cross-over trial. For 28 d participants ingested (i) 500 ml blood orange juice providing 50 mg anthocyanins/d and (ii) 500 ml blonde orange juice without anthocyanins. There was a minimum 3-week washout period between treatments. LDL-cholesterol and other biomarkers associated with CVD risk and glycaemia were assessed at the start and end of each treatment period. No significant differences were observed in total, HDL- and LDL-cholesterol, TAG, glucose, fructosamine, nitric oxide, C-reactive protein, aortic systolic blood pressure and diastolic blood pressure or carotid-femoral and brachial-ankle pulse wave veloci...Continue Reading

Associated Clinical Trials

References

Feb 9, 2008·The American Journal of Clinical Nutrition·Iris ErlundAntti Jula
Dec 8, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C M Gurrola-DíazJ F Gómez-Leyva
Nov 26, 2010·The American Journal of Clinical Nutrition·Aedín CassidyEric B Rimm
Mar 18, 2011·The American Journal of Clinical Nutrition·Mustali M DohadwalaJoseph A Vita
Apr 12, 2012·The American Journal of Clinical Nutrition·Silvio BuscemiGiovanbattista Rini
Aug 22, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Y ZhuY Yang
Aug 24, 2012·The American Journal of Clinical Nutrition·Amy JenningsAedín Cassidy
Feb 5, 2015·Current Hypertension Reports·Queenie ChanPaul Elliott
Jan 14, 2016·Nutrients·Taylor C WallaceCara L Frankenfeld
Feb 18, 2017·International Journal of Molecular Sciences·John OverallSlavko Komarnytsky

❮ Previous
Next ❯

Citations

Aug 31, 2018·International Journal of Food Sciences and Nutrition·Jiaojiao ZhangPatricia Reboredo-Rodriguez
Oct 16, 2019·Journal of Cardiovascular Pharmacology·Kazuo Yamagata, Yukio Yamori
Mar 4, 2020·Annual Review of Food Science and Technology·Elvira Gonzalez de MejiaMary Ann Lila
Mar 21, 2020·Molecular Nutrition & Food Research·Adrián Cortés-MartínJuan Carlos Espín
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roberto MattioliPaula Silva
Jun 7, 2020·Journal of Physiology and Biochemistry·Francisco LesVíctor López
Feb 8, 2020·Nutrients·María-Teresa García-Conesa, Mar Larrosa
May 21, 2021·Critical Reviews in Food Science and Nutrition·Farah J Tadros, Jeanette Mary Andrade
Jun 3, 2021·Biomolecules·Ioana MozosAtanas G Atanasov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.