4,4'-Diaponeurosporene-Producing Bacillus subtilis Promotes the Development of the Mucosal Immune System of the Piglet Gut

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Yuchao JingQian Yang

Abstract

Gut mucosal immune responses are known to act as the first line of defense against invasion of pathogenic microorganisms. Piglets have an incompletely developed gut mucosal immune system, making them sensitive to intestinal infections. Promoting the development of the mucosal immune system will increase the pathogen resistance of piglets. The aim of the present study was to investigate the effect of carotenoid (4,4'-diaponeurosporene)-producing Bacillus subtilis (B.s-Dia) on intestinal mucosal immunity in piglets. We showed that oral administration to piglets of B.s-Dia remarkably improved the development of Peyer's patches (PPs) (P < 0.01), and increased villus height (P < 0.01) and colon crypt depth (P < 0.01). In addition, B.s-Dia also increased the number of intraepithelial lymphocytes (P < 0.01), while Bacillus subtilis (B.s) had no significant influence on it (P > 0.05). Moreover, B.s-Dia also increased the number of SIgA+ cells (P < 0.01). Oral administration of either B.s or B.s-Dia increased the number of CD4+ and CD8+ cells in ileum lamina propria (P < 0.01). These results indicate that B.s-Dia contributes to a higher extent to porcine mucosal immune system development than B.s, and might serve as an immunopotentiator...Continue Reading

References

Apr 1, 1985·Journal of Animal Science·S Brief, B P Chew
Jan 1, 1994·International Archives of Allergy and Immunology·M BaileyF J Bourne
May 1, 1993·Journal of Animal Science·M T Coffey, J H Britt
Jan 1, 1996·Critical Reviews in Microbiology·J Wang, D Y Fung
Dec 5, 2002·Archiv für Tierernährung·Xianhong GuRuiping She
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·John E ButlerDavid Francis
Mar 5, 2003·Current Opinion in Microbiology·Francesca Granucci, Paola Ricciardi-Castagnoli
Jan 6, 2004·The Journal of Nutrition·Boon P Chew, Jean Soon Park
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ki-Jong RheeKatherine L Knight
Jan 30, 2004·The Journal of Nutrition·Erwin G ZoetendalH Rex Gaskins
Mar 12, 2004·Clinical and Diagnostic Laboratory Immunology·Michael BaileyChristopher R Stokes
Sep 3, 2004·Nature Reviews. Immunology·Hiroshi Kiyono, Satoshi Fukuyama
Nov 16, 2004·Journal of Animal Science·E G ManzanillaJ Gasa
Feb 24, 2006·Nature Reviews. Immunology·Marian R Neutra, Pamela A Kozlowski
Sep 3, 2008·Developmental and Comparative Immunology·Marek Sinkora, John E Butler
Sep 9, 2008·Developmental and Comparative Immunology·Hermann-Josef Rothkötter
Apr 13, 2010·The Veterinary Journal·Gerard HuyghebaertFilip Van Immerseel
Jul 3, 2010·American Journal of Veterinary Research·Frank M AarestrupHenrik C Wegener
Aug 10, 2010·Nature Reviews. Microbiology·Richard A Strugnell, Odilia L C Wijburg
Jan 12, 2011·Annual Review of Immunology·Andrea CeruttiAlejo Chorny
Jun 18, 2011·Nature Reviews. Immunology·Hilde CheroutreDaniel Mucida
Dec 8, 2011·Digestive Diseases and Sciences·Suzanne M AbimoslehGordon S Howarth
Jun 5, 2012·Seminars in Immunopathology·Valérie AbadieBana Jabri
Oct 12, 2012·The American Journal of Clinical Nutrition·Alfred Sommer, Krishna S Vyas
Jul 16, 2013·Tropical Animal Health and Production·Michel RakotoharinomeVincent Porphyre
Oct 12, 2013·Lab on a Chip·Yuli WangNancy L Allbritton
May 27, 2014·Frontiers in Microbiology·Guyue ChengZonghui Yuan
Aug 6, 2014·International Journal of Pharmaceutics·Beatriz Lasa-SaracíbarMaria J Blanco-Prieto
Dec 3, 2014·Vaccine·Aayam LamichhaneHiroshi Kiyonoa
Jan 21, 2015·Journal of Agricultural and Food Chemistry·Takahiro YamaguchiYoshimasa Yamamoto
Mar 10, 2015·Developmental and Comparative Immunology·Hana PotockovaMarek Sinkora
Jul 15, 2015·Trends in Immunology·Andrew J MacphersonKathy D McCoy
Oct 3, 2015·Veterinary Immunology and Immunopathology·Tatsuya MatsubaraHitoshi Kitagawa
Jun 13, 2018·Journal of Morphology·Yunhan YangQian Yang
Jul 31, 2018·Life Sciences·Caio Pupin RosaLeonardo Augusto de Almeida

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