443 paediatric cases of malignant melanoma registered with the German Central Malignant Melanoma Registry between 1983 and 2011

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Ines B BrechtUlrike Leiter

Abstract

Malignant melanoma is a very rare paediatric tumour. This study was performed in order to understand clinical features and prognosis of malignant melanoma in children and adolescents. 443 patients ⩽ 18 years of age with malignant melanoma were prospectively registered with the German Central Malignant Melanoma Registry between 1983 and 2011. Cases were collected from 58 participating centres. 276 paediatric cases with a follow-up >3 months were evaluated for survival probabilities and prognostic factors by Kaplan-Meier method. Age of diagnosis ranged from 3 months to 18 years (median age 16 years). The male to female ratio was 0.8 (202 male, 240 female). Most melanoma were located at the trunk (n = 195) and the lower extremity (n = 114). Patients with >3 months of follow-up (median 55 months) showed an overall survival (OS) of 94.8% in 5 years. Survival according to tumour stage was 98.5% for stage I (n = 190), 91.1% for stage II (n = 39) and 53.0% for stage III/IV tumours (n = 11). Worse outcome was seen in patients with nodular melanoma (OS 77.9%, n = 42) compared to superficial spread histotype (OS 100%, n = 138) or other histotype (OS 96.9%, n = 88) (p < 0.0001), in case of thicker tumours (Clark level IV or V, OS 87.1%, n ...Continue Reading

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Citations

Jun 28, 2016·Pediatric Blood & Cancer·Yves RéguerreLudovic Martin
Mar 21, 2018·Children·Klaus Rose, Jane M Grant-Kels
Jan 20, 2018·Pediatric Blood & Cancer·Ines B BrechtAndrea Ferrari
Oct 29, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·C A M EggenL M Hollestein
Jul 4, 2018·Pediatric Blood & Cancer·Alice IndiniAndrea Ferrari
Apr 28, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·C StefanakiA Stratigos
Apr 7, 2016·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jana VolejnikovaVladimir Mihal
Apr 3, 2018·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Chen YangLouis P Dehner
Oct 24, 2020·Journal of Cutaneous Medicine and Surgery·Fatmah AlZahraniLoretta Fiorillo
Mar 13, 2021·Surgical Oncology Clinics of North America·Jennifer H AldrinkMary Austin
Oct 13, 2017·Journal of the American Academy of Dermatology·Cristina CarreraAshfaq A Marghoob

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