PMID: 3746825Sep 1, 1986Paper

4,5-Disubstituted primaquine analogues as potential antimalarial agents

Journal of Medicinal Chemistry
F I CarrollC P Linn

Abstract

Three 4,5-disubstituted primaquine analogues were synthesized and evaluated for radical curative activity against Plasmodium cynomolgi in rhesus monkeys. One of the compounds showed moderate activity; however, none of the three compounds were as active as the lead compounds 5-methoxy-4-methylprimaquine and 4-(methoxy-methyl)-5-[m-(trifluoromethyl)phenoxy]primaquine.

Citations

Jul 8, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·V K DuaV P Sharma

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