45-year-old male with symptomatic mass in the frontal lobe.

Brain Pathology
Wolf MuellerA von Deimling

Abstract

A 45-year-old male patient developed focal seizures in his right arm. Neuroimaging demonstrated a tumor of the left frontal lobe. Tumor classification was undecided after stereotactic biopsy. Neuropathological examination of the open biopsy specimen revealed overlapping morphological features of an oligodendroglioma and a central neurocytoma. Groups of tumor cell featured the typical "fried egg" appearance seen in oligodendroglioma; microcalcifications and a network of branching non-proliferating vessels were present. Neurocytoma-like features included small nucleus-free areas of neuropil and perivascular pseudorosettes. Neuron specific enolase was strongly expressed cytoplasmically in the tumor cells and the "neuropil islands" were found to express synaptophysin. The final diagnosis of an oligodendroglioma with neurocytic differentiation was based on tumor location, clinicopathological findings and diagnostic genotyping. Combined loss of heterozygosity (LOH) on the short arm of chromosome 1 (1p) and the long arm of chromosome 19 (19q), the "molecular signature" of oligodendrogliomas, was revealed. Besides supporting the diagnosis of an oligodendroglioma, the molecular data allow for additional therapeutic options. These tumors...Continue Reading

References

Jul 1, 1993·Brain Pathology·J HassounP Kleihues
Oct 17, 1998·Journal of the National Cancer Institute·J G CairncrossD N Louis
Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J S SmithR B Jenkins
Jul 11, 2001·Advances in Anatomic Pathology·A Perry
Nov 15, 2002·Journal of Neuropathology and Experimental Neurology·Arie PerryJohan M Kros

❮ Previous
Next ❯

Citations

Nov 30, 2014·Neurosurgery Clinics of North America·Phillip A BonneyMichael E Sughrue
Oct 5, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Ari J KaneAndrew T Parsa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.