46-Year Trends in Systemic Lupus Erythematosus Mortality in the United States, 1968 to 2013: A Nationwide Population-Based Study

Annals of Internal Medicine
Eric Y YenRam R Singh

Abstract

No large population-based studies have been done on systemic lupus erythematosus (SLE) mortality trends in the United States. To identify secular trends and population characteristics associated with SLE mortality. Population-based study using a national mortality database and census data. United States. All U.S. residents, 1968 through 2013. Joinpoint trend analysis of annual age-standardized mortality rates (ASMRs) for SLE and non-SLE causes by sex, race/ethnicity, and geographic region; multiple logistic regression analysis to determine independent associations of demographic variables and period with SLE mortality. There were 50 249 SLE deaths and 100 851 288 non-SLE deaths from 1968 through 2013. Over this period, the SLE ASMR decreased less than the non-SLE ASMR, with a 34.6% cumulative increase in the ratio of the former to the latter. The non-SLE ASMR decreased every year starting in 1968, whereas the SLE ASMR decreased between 1968 and 1975, increased between 1975 and 1999, and decreased thereafter. Similar patterns were seen in both sexes, among black persons, and in the South. However, statistically significant increases in the SLE ASMR did not occur among white persons over the 46-year period. Females, black persons...Continue Reading

Citations

Oct 20, 2018·Expert Review of Clinical Immunology·Vanessa Ocampo-PiraquiveGabriel J Tobón
Jan 9, 2019·Clinical Science·Mathilde L BonnemaisonErika I Boesen
Dec 28, 2018·Rheumatology·Chang-Fu KuoMichael Doherty
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Nov 26, 2019·International Journal of Rheumatic Diseases·Ga Young AhnSang-Cheol Bae
Jun 2, 2020·Annals of Internal Medicine·Marianthi Kiriakidou, Cathy Lee Ching
May 8, 2020·Arthritis & Rheumatology·Candace H Feldman, Rosalind Ramsey-Goldman
Aug 26, 2020·Lupus·Juan Carlos Hernández-RodríguezJose Juan Pereyra-Rodríguez
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Jan 26, 2021·Journal of Translational Autoimmunity·Michael Battaglia, Lee Ann Garrett-Sinha
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Aug 5, 2021·Nature Reviews. Rheumatology·Megan R W BarberRosalind Ramsey-Goldman
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Jan 27, 2022·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kentaro NishiShuichi Ito

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