PMID: 7145839Apr 1, 1982Paper

46,XX/46XY chromosome complement in amniotic fluid cell culture followed by the birth of a normal female child

Prenatal Diagnosis
A HunterD Tomkins


Experience indicates that the most likely explanation for a mixture of 46,XX/46,XY cells in an amniotic fluid sample is that of maternal cell contamination and that a normal male child is to be expected at birth. We report the bith of a normal female child following prenatal diagnosis of such a mixture. Extensive postnatal studies failed to reveal an XY cell line. The possible sources of the XY cell line are discussed, as are the various techniques that were applied in an effort to discover it's origin. Cross-contamination of samples could be ruled out and there was no evidence of an unsuspected twin pregnancy. It is clear from this case that not all 46,XX/46,XY results obtained in amniotic fluid can be assumed to represent maternal cell contamination and some effort should be made to eliminate other potential sources for such a mixture.


Jan 25, 1979·The New England Journal of Medicine·M S GolbusB D Hall
Nov 1, 1977·British Journal of Obstetrics and Gynaecology·B GoldmanB Padeh
Jun 1, 1977·The Journal of Pediatrics·F J DillH Hoehn
May 1, 1975·Clinical Genetics·G R SutherlandA D Bain
Jan 1, 1980·Human Genetics·J P FrynsH Van den Berghe

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Mar 1, 1987·Journal of Medical Genetics·O ZuffardiC E Ford
Jun 1, 1983·American Journal of Medical Genetics·P A Benn, L Y Hsu
Jul 1, 1988·Prenatal Diagnosis·A S FreibergJ Mann
Mar 1, 1994·American Journal of Medical Genetics·T C Falik-BorensteinR R Schreck

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