PMID: 5171934Dec 1, 1971Paper

47 Calcium abosrption in parenchymatous and biliary liver disease

Gut
M J WheltonS Sherlock

Abstract

As measured by whole body retention of isotopic calcium given in milk, absorption of calcium was impaired in 10 patients with chronic parenchymal non-biliary liver disease who were icteric. Mean absorption was normal in 15 patients with parenchymal liver disease who were anicteric although some individual patients absorbed less than any of the controls. Depressed absorption of calcium was seen in 10 patients with primary biliary cirrhosis and seven patients with intra- or extra-hepatic biliary obstructive disease. The most likely cause for this malabsorption is reduced bile salt secretion into the intestinal lumen which impairs vitamin D and fat absorption. The finding that parenteral vitamin D increased calcium absorption to normal levels in five patients with primary biliary cirrhosis suggests that deficiency of this vitamin is a major and correctable factor leading to calcium malabsorption in such patients. Precipitation of calcium salts by excess intraluminal fat appears to be a further possible factor reducing calcium absorption in these patients. These findings emphasize the importance of parenteral vitamin D therapy in patients with chronic obstructive biliary diseases. They also suggest that certain patients with chroni...Continue Reading

References

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Citations

Dec 9, 1975·European Journal of Pediatrics·A KobayashiY Ohbe
Jan 1, 1974·Pediatric Radiology·P S Thomas, J F Glasgow
May 1, 1979·Irish Journal of Medical Science·M J Whelton
Jul 1, 1974·Irish Journal of Medical Science·M J Whelton
Feb 1, 1974·Archives of Disease in Childhood·A KobayashiY Nagashima
Apr 25, 2012·Nature Reviews. Endocrinology·Bikram S BalTimothy R Koch
Oct 1, 1986·Gastrointestinal Endoscopy·A Salmi
Apr 1, 1985·British Journal of Diseases of the Chest·A J WilliamsD E Stableforth
Mar 1, 1981·The Journal of Surgical Research·J KashtanJ W Holcroft
Nov 1, 1977·American Journal of Surgery·W I Onuigbo
Mar 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M BengoaI H Rosenberg
Sep 1, 1990·Journal of Hepatology·A SalmiC Rusconi
Mar 1, 1980·Clinics in Endocrinology and Metabolism·S C Meredith, I H Rosenberg
Jan 1, 1988·American Journal of Surgery·M J Orloff
Dec 1, 1996·Journal of Gastroenterology and Hepatology·A NakanoH Abe
Jan 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H Rosen
Jun 1, 1974·Postgraduate Medical Journal·R B Stern, R Williams
May 1, 1973·Journal of Clinical Pathology·R N MacSween
Dec 1, 1979·Irish Journal of Medical Science·M J Whelton
Apr 1, 1982·Scandinavian Journal of Gastroenterology·A DanielssonS E Larsson

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