4.7-T diffusion tensor imaging of acute traumatic peripheral nerve injury

Neurosurgical Focus
Richard B BoyerWesley P Thayer

Abstract

Diagnosis and management of peripheral nerve injury is complicated by the inability to assess microstructural features of injured nerve fibers via clinical examination and electrophysiology. Diffusion tensor imaging (DTI) has been shown to accurately detect nerve injury and regeneration in crush models of peripheral nerve injury, but no prior studies have been conducted on nerve transection, a surgical emergency that can lead to permanent weakness or paralysis. Acute sciatic nerve injuries were performed microsurgically to produce multiple grades of nerve transection in rats that were harvested 1 hour after surgery. High-resolution diffusion tensor images from ex vivo sciatic nerves were obtained using diffusion-weighted spin-echo acquisitions at 4.7 T. Fractional anisotropy was significantly reduced at the injury sites of transected rats compared with sham rats. Additionally, minor eigenvalues and radial diffusivity were profoundly elevated at all injury sites and were negatively correlated to the degree of injury. Diffusion tensor tractography showed discontinuities at all injury sites and significantly reduced continuous tract counts. These findings demonstrate that high-resolution DTI is a promising tool for acute diagnosis...Continue Reading

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Citations

Dec 1, 2017·Journal of Orthopaedic Surgery and Research·Yasushi WakoSeiji Ohtori
Feb 9, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Teodoro Martín NoguerolAntonio Luna
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Jan 7, 2021·Annals of Clinical and Translational Neurology·Michael D PridmoreRichard D Dortch

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Methods Mentioned

BETA
amputation
dissection
imaging techniques

Software Mentioned

GraphPad
Prism
MATLAB
ExploreDTI

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