4D DMLC leaf sequencing to minimize organ at risk dose in moving anatomy

Medical Physics
Lech PapiezRobert Timmerman

Abstract

The most favorable treatment for moving body anatomy should aim at utilizing organ motion to minimize the dose to sensitive structures without compromising the dose delivered to the target. The solution of the problem of appropriate intensity redistribution over different phases of body motion is achievable in dynamic multileaf collimator (DMLC) intensity modulated radiation therapy delivery, due to the fact that multiple solutions are admissible for imposing the same intensity map over a moving target in this technique of irradiation. The realization of this type of delivery provides a treatment methodology that delivers treatment plans for moving patient anatomy that are superior to any treatments possible for static patient body anatomy. This paper is devoted to exploring this idea. To this end, a simple, though clinically realistic example is developed and presented that shows modified DMLC leaf motions that deliver a predetermined intensity to a moving target while reducing the dose delivered to organs at risk.

References

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Citations

Aug 14, 2009·Medical Physics·Ramin M Abolfath, Lech Papiez
Dec 17, 2008·Medical Physics·Lech Papiez, Ramin M Abolfath
Oct 5, 2013·Medical Physics·Eric W PepinHiroki Shirato
May 14, 2014·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Christian Graeff
Jan 5, 2016·International Journal of Radiation Oncology, Biology, Physics·Wei LiuMartin Bues
May 5, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hidenobu Tachibana, Amit Sawant
Jun 25, 2009·Physics in Medicine and Biology·Weiguo LuGustavo H Olivera
Dec 2, 2017·Journal of Applied Clinical Medical Physics·Shahad M Al-WardBrian M Keller
Aug 2, 2016·Physics in Medicine and Biology·A ModiriA Sawant
May 30, 2009·Physics in Medicine and Biology·Yelin SuhPaul J Keall
Jan 18, 2013·Physics in Medicine and Biology·E ChinK Otto

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