4D Printing of Shape Memory Vascular Stent Based on βCD-g-Polycaprolactone.

Macromolecular Rapid Communications
Yanyi ZhouYaoming Zhang

Abstract

The 4D-printing technology is applied to fabricate a shape memory peripheral stent with good biocompatibility, which sustains long-term drug release. The star polymer s-PCL is prepared by ring opening polymerization of ε-caprolactone with the -OH of β-cyclodextrin (βCD) as initiator, and then the s-PCL is modified with acrylate endgroup which allows the polymerization under UV light to form the crosslinking network c-PCL. Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body. The radial support of the 4D-printed stent is 0.56 ± 0.11 N and is equivalent to that of commercial stent. The cell adhesion and proliferation results show a good biocompatibility of the stent with human umbilical vein endothelial cells. Due to the presence of βCD, the wettability and biocompatibility of the materials are improved, and the sustained paclitaxel release based on the host-guest complexion shows the potential of the drug-loaded stent for long-term release. This study provides a new strategy to solve the urgent need of small-...Continue Reading

References

Mar 4, 2006·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S SarkarA M Seifalian
Nov 6, 2007·Journal of Cellular and Molecular Medicine·Wen Jie ZhangYilin Cao
Mar 6, 2012·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Animesh RathoreChristopher Breuer
Feb 19, 2014·ACS Applied Materials & Interfaces·Jonathan SobocinskiJoel Lyskawa
Dec 6, 2016·Macromolecular Rapid Communications·Matt ZarekDaniel Cohn
Sep 25, 2017·Advanced Healthcare Materials·Gregory I PetersonMatthew L Becker
Aug 28, 2019·Advanced Materials·Yong Cheol ShinHak-Joon Sung
Jun 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Young-Jin Kim, Yukiko T Matsunaga

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