PMID: 6538202Mar 1, 1984Paper

4F2 monoclonal antibody recognizes a surface antigen on spread human fibroblasts of embryonic but not of adult origin

The Journal of Cell Biology
B AzzaroneA S Fauci

Abstract

The 4F2 monoclonal antibody (mAb) has been shown to recognize a 120-kilodalton glycoprotein expressed on the cell surface of human peripheral blood monocytes, activated (but not resting) T or B cells, and T and B lymphoblastoid cell lines. In this report we show that 4F2 mAb specifically binds to the surface of adherent human embryonic fibroblasts but fails to bind to normal adult fibroblasts. Moreover, 4F2 antigen was expressed on sarcoma-derived or SV40-transformed adult fibroblastic cells. Finally, addition of 4F2 mAb inhibited the growth of cultured HT-1080 fibrosarcoma cell line, but had no inhibitory effect on various embryonic and adult normal or transformed fibroblasts.

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Citations

Jan 1, 1986·Immunologic Research·L K Jung
Mar 1, 1987·Mechanisms of Ageing and Development·B M Stanulis-Praeger
Aug 1, 1993·Immunology and Cell Biology·B R Yacyshyn
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J A LumadueF H Ruddle
Sep 11, 2013·The Journal of Clinical Investigation·Kwan-Hyuck BaekSandra Ryeom
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Jun 12, 2021·Journal for Immunotherapy of Cancer·Giulia PellizzariSophia N Karagiannis
Jun 1, 1987·Experimental Cell Research·S MatsuhashiK Hori

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