4p trisomy syndrome: report of 4 additional cases and segregation analysis of 21 families with different translocations

American Journal of Medical Genetics
J CraneA Smith

Abstract

Thirty reports of partial 4p trisomy have been published. The manifestations and cytogenetic findings in four additional cases from two families are described in the present paper. Segregation analysis has been performed on the 21 families reported to date. The risk of having unbalanced offspring was the same in carrier mothers and carrier fathers. The risk of trisomic offspring was 14%. Among phenotypically normal progeny, normal karyotypes and balanced translocation states occurred with about equal frequency.

References

Jan 1, 1977·American Journal of Medical Genetics·C H GonzalezJ M Opitz
Jan 1, 1978·Human Heredity·J G MortimerG F Smith
Oct 28, 1976·Human Genetics·T BauknechtW Vogel
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Dec 1, 1975·Journal of Medical Genetics·J M Darmady, M Seabright

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Citations

Nov 1, 1988·Journal of Medical Genetics·J L HuretJ Lejeune
Jun 1, 1995·European Journal of Pediatrics·S V PatelR S Verma
Feb 26, 2011·American Journal of Medical Genetics. Part a·Lingqian WuDesheng Liang
Sep 20, 2002·American Journal of Medical Genetics·A BattagliaJ C Carey
Sep 1, 1984·Journal of Clinical and Hospital Pharmacy·M C Allwood
Jun 13, 2000·JPEN. Journal of Parenteral and Enteral Nutrition·O MontejoJ Bonal
Jan 1, 1983·Clinical Genetics·M Preus, S Aymé

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