4S neuroblastoma: the long-term outcome

Pediatric Blood & Cancer
G A LevittC M Owens

Abstract

Stage 4S neuroblastoma is associated with a high rate of spontaneous maturation and involution, with survival rates of 70-90%. There is little long-term follow-up data describing the disease status or late effects. The aim of this study was to assess the clinical outcome and imaging findings in long-term survivors of 4S neuroblastoma. The patient population was identified from a single centre over 26 years. Twenty-five of 31 consecutive patients were long-term survivors. Five died from disease progression and one from cerebral palsy related complications. All survivors underwent clinical examination. Abdominal ultrasound scanning, liver function tests, hepatitis viral screen, and urinary catecholamines were performed. The mean age at diagnosis was 8 +/- 9 weeks with a mean age when studied of 11 years and 10 months +/- 8 years. Twenty of 25 had no significant clinical findings, three had disease associated clinical abnormalities (neurological, multiple subcutaneous nodules). Three patients had treatment related effects (small testes, urethral stricture, radiation induced soft tissue hypoplasia, post-surgical Horners syndrome). Persistant adrenal enlargement and calcification was noted in three patients. Twelve patients had abno...Continue Reading

References

Jan 1, 1990·Pediatric Hematology and Oncology·A CerveraJ S Malpas
Aug 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G M BrodeurF Hedborg
May 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M GuglielmiP Bruzzi
Dec 1, 1996·Medical and Pediatric Oncology·L L HsuG J D'Angio
Jul 1, 1996·Klinische Pädiatrie·A ClaviezF Berthold
Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H J NickersonJ Lukens
Sep 16, 2000·Pediatric Hematology and Oncology·S M Yule, J Anderson
May 31, 2001·Journal of Pediatric Surgery·K KatoY Tanaka
May 7, 2002·Journal of Pediatric Hematology/oncology·Stephen RobertsDaniel Robie

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Citations

Jul 1, 2009·Journal of Pediatric Hematology/oncology·Guzide Burça AydnNebil Büyükpamukçu
Nov 25, 2005·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Georgia Papaioannou, Kieran McHugh
Jun 1, 2012·Critical Reviews in Clinical Laboratory Sciences·Cormac Owens, Meredith Irwin
Dec 2, 2015·Oncology Letters·Jing-Bo ShaoHui Jiang
Mar 4, 2011·Pediatric Blood & Cancer·Amy E FrenchPaul C Nathan
May 19, 2012·Pediatric Blood & Cancer·Michael WeintraubShoshana Revel-Vilk
Jul 8, 2011·The Cochrane Database of Systematic Reviews·Renée L MulderLeontien Cm Kremer
Apr 16, 2019·The Cochrane Database of Systematic Reviews·Renée L MulderElvira C van Dalen
Nov 19, 2019·Pediatric Blood & Cancer·Michelle L TasMax M van Noesel
Feb 16, 2021·Clinics in Perinatology·Sanyukta K Janardan, Karen E Effinger

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