PMID: 6172181Dec 28, 1981Paper

4S RNA is transported axonally in normal and regenerating axons of the sciatic nerves of rats

Brain Research
T D LindquistR M Gould

Abstract

Experiments were designed to determine if following injection of [3H]uridine into the lumbar spinal cord of the rat, [3H]RNA could be demonstrated within axons of the sciatic nerve, and if 4S RNA is the predominant RNA species present in these axons. In one experiment the left sciatic nerve of a rat was crushed. Two days later 170 microCi of [3H]uridine was injected into the vicinity of the lumbar ventral horn cells. Ten days after injection, rats were sacrificed and sciatic nerves were prepared for autoradiography. Photomicrographs were taken of labeled areas of intact and regenerating nerves and grains were counted over Schwann cells, myelin, axons and other unspecified areas. In both intact and regenerating sciatic nerves more than 20% of the silver grains were associated with motor axons and approximately 40% were found over cytoplasm of Schwann cells surrounding these axons. These data indicate an intra-axonal localization of RNA in sciatic nerve axons, as well as an active transfer of RNA precursors from axons to their surrounding Schwann cels. In separate studies, the left sciatic nerve was crushed and 10 days later [3H]uridine was bilaterally injected intraspinally into 6 rats. Four control rats were sacrificed at 14 or...Continue Reading

References

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Citations

Jun 1, 1985·Journal of Neurochemistry·T D LindquistN A Ingoglia
Oct 2, 2020·Physiological Reviews·Rico SchieweckMichael A Kiebler
Aug 1, 1986·Journal of Neurochemistry·D J Gower, M Tytell

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