PMID: 9004774Jan 1, 1996Paper

5-[125]iodo-2'-deoxyuridine in the radiotherapy of solid CNS tumors in rats

Acta Oncologica
A I Kassis, S J Adelstein

Abstract

We have been investigating the therapeutic efficacy of the thymidine analog 5-iodo-2'-deoxyuridine (IUdR) when radiolabeled with the Auger electron emitter 125I in rats bearing intrathecal (i.t.) or intracerebral (i.c.) 9L gliosarcoma solid tumors. [125I]IUdR was infused i.t. (via subarachnoid catheters) or intracerebrally over a 5- or 2-day period; equimolar concentrations of [127I]IUdR were infused into control animals. Hind-leg paralysis and/or survival were followed over time. The results indicate that compared with [127I]IUdR, rats bearing intrathecal tumors and infused i.t. with [125I]IUdR showed significant prolongation of the onset of median paralysis (15.2 versus 9 days). Similarly, the median survival of rats bearing intracerebral tumors and infused i.c. with [125I]IUdR was significantly increased (24 versus 17 days). The data substantiate the antineoplastic potential of [125I]IUdR and indicate a promising role for this radiopharmaceutical in the treatment of CNS cancers.

References

Jan 15, 1979·Biochemical and Biophysical Research Communications·S L Commerford, D D Joel
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Nov 1, 1991·International Journal of Radiation Oncology, Biology, Physics·J Baranowska-KortylewiczA I Kassis
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Citations

May 31, 2001·Australasian Radiology·D R Wigg, G W Morgan
Sep 5, 2003·Cancer Biotherapy & Radiopharmaceuticals·S James AdelsteinGiuliano Mariani
Mar 15, 2005·International Journal of Radiation Biology·Amin I Kassis
Jun 27, 2012·International Journal of Radiation Biology·Pichumani BalagurumoorthyAmin I Kassis

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