5-ALA fluorescence and laser Doppler flowmetry for guidance in a stereotactic brain tumor biopsy

Biomedical Optics Express
Neda Haj-HosseiniKarin Wårdell

Abstract

A fiber optic probe was developed for guidance during stereotactic brain biopsy procedures to target tumor tissue and reduce the risk of hemorrhage. The probe was connected to a setup for the measurement of 5-aminolevulinic acid (5-ALA) induced fluorescence and microvascular blood flow. Along three stereotactic trajectories, fluorescence (n = 109) and laser Doppler flowmetry (LDF) (n = 144) measurements were done in millimeter increments. The recorded signals were compared to histopathology and radiology images. The median ratio of protoporphyrin IX (PpIX) fluorescence and autofluorescence (AF) in the tumor was considerably higher than the marginal zone (17.3 vs 0.9). The blood flow showed two high spots (3%) in total. The proposed setup allows simultaneous and real-time detection of tumor tissue and microvascular blood flow for tracking the vessels.

References

Aug 22, 2007·Stereotactic and Functional Neurosurgery·Karin WårdellMarwan I Hariz
Apr 3, 2008·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Paul N KongkhamMark Bernstein
Feb 19, 2009·Stereotactic and Functional Neurosurgery·Johannes D JohanssonKarin Wårdell
Sep 22, 2009·Clinical Neurology and Neurosurgery·Ching-Chang ChenYin-Cheng Huang
Jan 16, 2010·Lasers in Surgery and Medicine·Neda Haj-HosseiniKarin Wårdell
Nov 9, 2010·NeuroImage·Pramod V ButteLaura Marcu
Mar 14, 2012·Journal of Surgical Technique and Case Report·Saeid AbrishamkarSalman Abbasifard
May 18, 2013·Surgical Neurology International·J Dawn WatersClark C Chen
May 3, 2014·Journal of Neurosurgery·Michael E IvanPaul S Larson
Mar 31, 2015·Journal of Neurosurgery·Keiya IijimaYuhei Yoshimoto
Mar 31, 2015·Photodiagnosis and Photodynamic Therapy·Neda Haj-HosseiniKarin Wårdell
May 27, 2015·World Neurosurgery·Hani MaloneAlfred I Neugut
Jun 25, 2015·Medical & Biological Engineering & Computing·Peter RejmstadKarin Wårdell
Jul 24, 2015·Biomedical Optics Express·Joannie DesrochesFrédéric Leblond
Oct 8, 2016·Journal of Biophotonics·Niklas A MarkwardtAdrian Rühm
Feb 23, 2017·Photodiagnosis and Photodynamic Therapy·Johan C O RichterKarin Wårdell
Sep 21, 2017·International Journal of Computer Assisted Radiology and Surgery·David BlackNeda Haj-Hosseini
Jan 5, 2018·Stereotactic and Functional Neurosurgery·Peter ZsigmondKarin Wårdell

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Citations

Dec 27, 2018·Science Advances·Hari RamakonarRobert A McLaughlin
Jun 4, 2021·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·Eric T RasmussenCameron N Riviere
Jul 1, 2021·Operative Neurosurgery·Johan RichterKarin Wårdell

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