5-alkylresorcinols from Merulius incarnatus

Journal of Natural Products
Wentao Jin, Jordan K Zjawiony

Abstract

Two new, 5-heptadeca-8'Z,11'Z,16-trienylresorcinol (1) and 5-heptadeca-9'E,11'Z,16-trienylresorcinol (2), and six known 5-alkylresorcinols (3-8) were isolated from the mushroom Merulius incarnatus. Compound 2 is the first 5-alkylresorcinol derivative that contains a trans-cis conjugated double bond system. Compounds 1, 2, 5, 6, 7, and 8 were found to inhibit methacillin-resistant Staphylococcus aureus (MRSA) with IC(50) values of 2.5, 15, 9.5, 8.0, 5.0, and 6.5 microg/mL, respectively. Compound 1 was also active against leishmania, with an IC(50) value of 3.6 microg/mL, and showed no cytotoxicity in our Vero cell test up to a concentration of 25 microg/mL. The structures of these isolates were determined by spectroscopic data including 1D and 2D NMR.

Citations

Jun 2, 2012·Journal of Chemical Ecology·Robert Vander Meer
Jul 4, 2012·Journal of Natural Products·Anja SchüfflerTill Opatz
Mar 10, 2010·Cellular and Molecular Life Sciences : CMLS·Maria Stasiuk, A Kozubek
Oct 8, 2019·3 Biotech·Adhiraj Dasgupta, Krishnendu Acharya
Jan 30, 2010·Natural Product Reports·Muhammad SaleemAbdul Jabbar
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hélène LevaiqueSébastien Pomel
Sep 26, 2014·Chemical Reviews·Hidayat HussainSimon Gibbons

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