5-Alpha-dihydroprogesterone formation in human placenta from 5alpha-pregnan-3beta/alpha-ol-20-ones and 5-pregnan-3beta-yl-20-one sulfate

The Journal of Steroid Biochemistry and Molecular Biology
R DombroskiP C MacDonald

Abstract

5Alpha-dihydroprogesterone (5alpha-DHP) is the immediate precursor of 5alpha-pregnan-3alpha-ol-20-one, a potent anxiolytic/anesthetic agent in all vertebrate animals tested, including humans. The levels of 5alpha-DHP in the plasma of pregnant women are very high; and during the third trimester of pregnancy, the blood production rate of this steroid may exceed 100 mg/24 h. 5Alpha-DHP in maternal plasma, however, cannot be accounted for totally by the metabolism of maternal plasma progesterone. This study was conducted to evaluate the possibility that 5alpha-DHP is synthesized in placenta from 5alpha-pregnan-3alpha/beta-ol-20-ones delivered to the trophoblast via the fetal umbilical blood. In incubations of placental minces with radiolabelled 5alpha-pregnan-3alpha/beta-ol-20-ones, there is extensive epimerization and the intermediate, 5alpha-DHP, is the major product. In other incubations, 5alpha-pregnan-3beta-ol-20-one-sulfate was hydrolysed and the liberated 5alpha-pregnan-3beta-ol-20-one was converted to 5alpha-DHP by homogenates of placental tissue, but 5alpha-pregnan-3beta-ol-20-one-sulfate was not. The oxidation of 5alpha-pregnan-3alpha/beta-ol-20-ones was concentrated in microsome-enriched preparations of placental tissue ...Continue Reading

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Citations

May 25, 2006·The Journal of Clinical Endocrinology and Metabolism·Helena HavlíkováLuboslav Stárka
Sep 10, 2011·The Journal of Endocrinology·Mark NixonRuth Andrew
May 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·F Lo, S Kaufman
Apr 12, 2002·Endocrine Reviews·Fernando M ReisFelice Petraglia
Dec 24, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Susan E Gilbert EvansMyroslava K Romach
Jul 16, 2010·Endocrine Reviews·Felice PetragliaJohn R G Challis
Dec 22, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Gerson D HernandezRoberta D Brinton
Jul 31, 2020·Frontiers in Neuroendocrinology·Inger Sundström-PoromaaEileen Luders
May 8, 2021·Scientific Reports·Rahel KlossnerCarine Gennari-Moser
Jul 12, 2017·Frontiers in Neuroendocrinology·E HolmbergT Bäckström

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