PMID: 9558487Apr 29, 1998Paper

5 alpha-reductase activity in the human hair follicle concentrates in the dermal papilla

Archives of Dermatological Research
W EichelerRolf Hoffmann

Abstract

Hair growth depends on a close interaction of different cell populations of the hair follicle. In certain regions of the body, androgens interfere with this highly regulated cooperation in a yet poorly understood manner. The response of hair follicles to androgens can be categorized as androgen-dependent, e.g. in the beard, androgen-sensitive, e.g. in the frontal scalp of affected individuals, or androgen-independent, e.g. in the occipital scalp. At the target cell level, the balance between 5 alpha-reductase, 17 beta-hydroxysteroid-dehydrogenase (17 beta-HSD) and 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) yields metabolites with different androgenic potential. We examined this target cell-specific androgen metabolism in microdissected intact sub-units of dermal papillae, connective tissue sheaths (CTS) and root sheaths. In dermal papillae, 5 alpha-reductase predominated with an accumulation of the strong androgen 5 alpha-dihydrotestosterone. The specific activity of 5 alpha-reductase in the papillae exceeded those in the other hair follicle compartments by a factor of at least 14 in the scalp (5.4, 0.4 and 0.1 pmol/h per mm3 in the papilla, CTS and root respectively and at least 80 in the beard (16.0, 0.2 and 0.4 pmol/...Continue Reading

Citations

Apr 26, 2002·Veterinary Dermatology·Christine B Bratka-RobiaElmar Bamberg
Aug 5, 2003·The Journal of Investigative Dermatology. Symposium Proceedings·Vladimir A Botchkarev, Jiro Kishimoto
Sep 2, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Florian GruberErwin Tschachler
Sep 10, 2011·The Journal of Endocrinology·Mark NixonRuth Andrew
Jun 18, 2005·Veterinary Dermatology·Elmar BambergGerda Wünsch
Mar 3, 2004·Veterinary Dermatology·Elmar BambergGerda Mitteregger
Jul 1, 2006·The Journal of Investigative Dermatology·Susan E RutbergDouglas Shander
Nov 26, 2002·The Journal of Investigative Dermatology·WenChieh ChenChristos C Zouboulis
Mar 12, 2002·The Journal of Investigative Dermatology·R HoffmannA Billich
Jun 12, 2004·The Journal of Investigative Dermatology·Kevin J McElweeRolf Hoffmann
Nov 16, 2012·The Journal of Investigative Dermatology·Man Ho ChoiBong Chul Chung
Jun 7, 2015·Journal of Theoretical Biology·Atanaska DobrevaN G Cogan
Sep 23, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·I O OliveiraP M Spritzer
Oct 31, 2018·Endocrinology·Joabel Tonellotto Dos SantosFabio Vasconcellos Comim
Oct 21, 2000·Endocrine Reviews·A Slominski, J Wortsman
Jan 12, 2001·Physiological Reviews·K S Stenn, R Paus

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