PMID: 8971292Dec 1, 1996Paper

5-amino salicylic acid absorption and metabolism in ulcerative colitis patients receiving maintenance sulphasalazine, olsalazine or mesalazine

Alimentary Pharmacology & Therapeutics
G L StretchJ M Rhodes

Abstract

All 5-aminosalicylic acid (5-ASA) preparations are potentially nephrotoxic, but there has been concern that newer delivery systems may increase this risk, either because of altered absorption or altered metabolism. Previous studies of 5-ASA absorption and excretion have usually either been performed in healthy controls or have only examined short-term therapy. 5-ASA and N-acetyl-5-ASA have therefore been measured in blood samples, and N-acetyl-5-ASA in urine samples, from patients with ulcerative colitis on long-term maintenance with different 5-ASA preparations and compared with sensitive markers of renal damage. Patients receiving mesalazine (Asacol) (n = 13), sulphasalazine (n = 12) or olsalazine (Dipentum) (n = 8), all at doses within the recommended range were studied. Six-hour and trough serum concentrations of 5-ASA and N-acetyl-5-ASA and 24-h urinary excretion of N-acetyl-5-ASA were measured by high-performance liquid chromatography. Absorption of 5-ASA, assessed as 24-h excretion of N-acetyl-5-ASA expressed as molar % of ingested dose, was greater in patients receiving mesalazine, 23.25 +/- 10.65% (mean +/- s.d.; n = 13), than those receiving sulphasalazine (11.16 +/- 10.52%, n = 12; P = 0.003) or olsalazine (9.70 +/- ...Continue Reading

Citations

Jan 24, 2007·Inflammatory Bowel Diseases·Javier P GisbertJosé Maté
Sep 16, 2010·Inflammatory Bowel Diseases·Konstantinos OikonomouSpiros Potamianos
May 17, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·U Klotz
Nov 14, 2012·Nature Reviews. Gastroenterology & Hepatology·Magnus Halland, Nicholas J Talley
Nov 30, 2012·The American Journal of Clinical Hypnosis·David Kraft
Mar 24, 2000·Journal of Clinical Gastroenterology·T SontaH Nawata
Dec 26, 2001·Journal of Pediatric Gastroenterology and Nutrition·Elizaveta IofelJames Markowitz
Sep 29, 2005·Inflammatory Bowel Diseases·Carmen CuffariGary R Lichtenstein
Jun 17, 2011·Nephron. Clinical Practice·Konstantinos A OikonomouSpyros P Potamianos
Apr 28, 2006·Scandinavian Journal of Gastroenterology·A Nilsson
Dec 21, 2002·The American Journal of Gastroenterology·William J Sandborn
May 12, 1998·The American Journal of Gastroenterology·D S PardiJ T McCarthy

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