PMID: 15677492Jan 29, 2005

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside causes acute hepatic insulin resistance in vivo

R Richard PencekDavid H Wasserman


The infusion of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) causes a rise in tissue concentrations of the AMP analog 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranotide (ZMP), which mimics an elevation of cellular AMP levels. The purpose of this work was to determine the effect of raising hepatic ZMP levels on hepatic insulin action in vivo. Dogs had sampling and infusion catheters as well as flow probes implanted 16 days before an experiment. After an 18-h fast, blood glucose was 82 +/- 1 mg/dl and basal net hepatic glucose output 1.5 +/- 0.2 mg . kg(-1) . min(-1). Dogs received portal venous glucose (3.2 mg . kg(-1) . min(-1)), peripheral venous somatostatin, and basal portal venous glucagon infusions from -90 to 60 min. Physiological hyperinsulinemia was established with a portal insulin infusion (1.2 mU . kg(-1) . min(-1)). Peripheral venous glucose infusion was used to clamp arterial blood glucose at 150 mg/dl. Starting at t = 0 min, dogs received portal venous AICAR infusions of 0, 1, or 2 mg . kg(-1) . min(-1). Net hepatic glucose uptake was 2.4 +/- 0.5 mg . kg(-1) . min(-1) (mean of all groups) before t = 0 min. In the absence of AICAR, net hepatic glucose uptake was 1.9 +/- 0.4 mg . kg(-1) . min(-...Continue Reading


Apr 15, 1996·Archives of Biochemistry and Biophysics·N ErcanFrank Q Nuttall
Jul 1, 1996·The Journal of Clinical Investigation·K S HamiltonDavid H Wasserman
Feb 4, 1999·Journal of Applied Physiology·C L Carlson, W W Winder
Apr 20, 2001·The Journal of Biological Chemistry·Susan AistonLoranne Agius
Jul 27, 2001·Diabetes Technology & Therapeutics·W W Winder
Aug 18, 2001·Journal of Applied Physiology·W W Winder
Mar 2, 2002·Diabetes·William G AschenbachL J Goodyear
Jun 14, 2002·Biochemical and Biophysical Research Communications·Amy E HalsethEric A Gulve
Jun 18, 2002·American Journal of Physiology. Endocrinology and Metabolism·Nacide Ercan-FangFrank Q Nuttall
Dec 13, 2002·Current Drug Targets. Immune, Endocrine and Metabolic Disorders·N Musi, L J Goodyear
Jan 28, 2003·Biochemical Society Transactions·N MusiL J Goodyear
Mar 11, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sarah L LongnusMichael F Allard
Jul 17, 2003·Acta Physiologica Scandinavica·N Musi, L J Goodyear
Mar 23, 2004·Biochemical and Biophysical Research Communications·Aina S LihnBjørn Richelsen
May 20, 2004·American Journal of Physiology. Endocrinology and Metabolism·Lubna Al-KhaliliGregory D Cartee


Sep 1, 2005·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·R Richard PencekDavid H Wasserman
Aug 8, 2009·The Journal of Clinical Investigation·Eric D BerglundDavid H Wasserman
May 16, 2012·Advances in Nutrition·Mary Courtney MooreA D Cherrington
Oct 7, 2011·Journal of Graduate Medical Education·Eileen MastersonCharles K Francis
Aug 13, 2010·Biomarkers in Medicine·Nikolaos P E KadoglouChristos D Liapis
Oct 22, 2005·Diabetes/metabolism Research and Reviews
Apr 11, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·P TessariA Tiengo
Jan 8, 2010·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Eunhui SeoHye-Jeong Lee
Mar 30, 2007·Diabetes, Obesity & Metabolism·J C Clapham, J R S Arch
Oct 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Raul C CamachoDavid H Wasserman
Jun 15, 2006·American Journal of Physiology. Endocrinology and Metabolism·Michael ChristopherFrank P Alford
Jan 18, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mohammed MukhtarLoranne Agius
Jan 24, 2008·American Journal of Physiology. Endocrinology and Metabolism·Mary Courtney MooreA D Cherrington
Jul 28, 2005·American Journal of Physiology. Endocrinology and Metabolism·Raul C CamachoDavid H Wasserman
Oct 16, 2007·Molecular and Cellular Biochemistry·Jennifer WallingtonMichael Alan Titheradge

Related Concepts

5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide monophosphate
Cyclic AMP, (R)-Isomer
Ba 2756
Blood Glucose
Canis familiaris
Compensatory Hyperinsulinemia
Intravenous Infusion Procedures
Insulin Sensitivity

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.