5'-aminoimidazole-4-carboxyamide-ribonucleoside-activated glucose transport is not prevented by nitric oxide synthase inhibition in rat isolated skeletal muscle

Clinical and Experimental Pharmacology & Physiology
T J StephensGlenn K McConell

Abstract

1. The nucleoside intermediate 5'-aminoimidazole-4-carboxyamide-ribonucleoside (AICAR) activates skeletal muscle AMP-activated protein kinase (AMPK) and increases glucose uptake. The AMPK phosphorylates neuronal nitric oxide synthase (nNOS)mu in skeletal muscle fibres. There is evidence that both AMPK and nNOSmu may be involved in the regulation of contraction-stimulated glucose uptake. 2. We examined whether both AICAR- and contraction-stimulated glucose uptake were mediated by NOS in rat skeletal muscle. 3. Rat isolated epitrochlearis muscles were subjected in vitro to electrically stimulated contractions for 10 min and/or incubated in the presence or absence of AICAR (2 mmol/L) or the NOS inhibitor NG-monomethyl-L-arginine (L-NMMA; 100 micromol/L). 4. Muscle contraction significantly (P < 0.05) altered the metabolic profile of the muscle. In contrast, AICAR and L-NMMA had no effect on the metabolic profile of the muscle, except that AICAR increased muscle 5'-aminoimidazole-4-carboxyamide-ribonucleotide (ZMP) and AICAR content. Nitric oxide synthase inhibition caused a small but significant (P < 0.05) reduction in basal 3-O-methylglucose transport, which was observed in all treatments. 5'-Aminoimidazole-4-carboxyamide-ribonuc...Continue Reading

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Citations

Sep 2, 2008·Clinical and Experimental Pharmacology & Physiology·Glenn K McConell, Glenn D Wadley
Mar 5, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert S Lee-YoungDavid H Wasserman
Nov 25, 2014·The Journal of Physiology·Lykke SylowThomas E Jensen
Aug 15, 2008·Acta Neurologica Scandinavica·V AgostiG Sorrentino
Aug 31, 2006·BMC Bioinformatics·Qingfeng Chen, Yi-Ping Phoebe Chen
Dec 5, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Glenn K McConell
Jul 23, 2005·Journal of Applied Physiology·Niels Jessen, Laurie J Goodyear
Jul 19, 2005·Physiology·Adam J Rose, Erik A Richter
Aug 18, 2005·American Journal of Physiology. Endocrinology and Metabolism·G K McConellG D Wadley
Jan 6, 2006·Exercise and Sport Sciences Reviews·Glenn K McConell, Bronwyn A Kingwell
Jun 15, 2006·American Journal of Physiology. Endocrinology and Metabolism·Michael ChristopherFrank P Alford
Jul 9, 2009·Physiological Reviews·Gregory R Steinberg, Bruce E Kemp
Oct 15, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Troy L MerryGlenn K McConell
Aug 1, 2013·Physiological Reviews·Erik A Richter, Mark Hargreaves
Oct 27, 2017·The Journal of Physiology·Xinmei ZhangGlenn K McConell
Jun 28, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pieter de LangeAntonia Lanni
Mar 25, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kari K KalliokoskiRobert Boushel
Dec 17, 2009·American Journal of Physiology. Endocrinology and Metabolism·Troy L MerryGlenn K McConell
Mar 19, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alex Bernard AddinsallNicole Stupka

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