5-Aminolaevulinic acid-induced photodynamic therapy and photodetection in Barrett's esophagus

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
P E Claydon, R Ackroyd

Abstract

Barrett's esophagus is a precursor of adenocarcinoma of the esophagus. This cancer has the fastest growing incidence of any solid tumor in the Western world. Surveillance of Barrett's esophagus is routinely undertaken to detect early malignant transformation. However, ablative endoscopic treatments are available and these can obliterate the abnormal epithelium, allowing neosquamous regrowth. Photodynamic therapy using 5-aminolaevulinic acid (ALA) is such a technique. In this non-thermal method of ablation, ALA is metabolized to produce the photosensitizer protoprophyrin IX. This, together with light and oxygen, produces local tissue destruction. Fluorescence detection using ALA has also been used to identify areas of dysplasia and thus enhance positive biopsy yield. The use of ALA in photodynamic therapy and photodetection is reviewed.

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Citations

Sep 22, 2010·Photochemistry and Photobiology·Ann JohanssonHerbert Stepp
Mar 9, 2007·Journal of Biomedical Optics·Christoph HolmerJoerg-Peter Ritz
Jul 2, 2005·Gastrointestinal Endoscopy Clinics of North America·Ronald W Yeh, George Triadafilopoulos
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Jun 20, 2007·Photochemistry and Photobiology·Chao ShengBrian W Pogue
Mar 29, 2006·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Stanley S Stylli, Andrew H Kaye

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