5-Aminosalicylic acid, a specific drug for ulcerative colitis

Scandinavian Journal of Gastroenterology
Øyvind HausoHelge Waldum

Abstract

The etiology of the inflammatory bowel diseases is unknown, although genetic factors play a role, and tobacco smoking has opposite effect on the two entities. Inflammation is central in the pathogenesis, and treatment is aiming to suppress it. The active part of salazopyrin, the oldest drug in use in the treatment of ulcerative colitis, is 5-aminosalicylic acid (5-ASA). In the present paper, we wanted to discuss the etiology and pathogenesis of ulcerative colitis in relation to the beneficial effects of 5-ASA and particularly whether this compound has a specific effect on ulcerative colitis. 5-ASA seems to have a selective positive effect on ulcerative colitis in inducing remission, preventing relapse and possibly reducing the risk of cancer. In contrast to other agents used in the treatment of ulcerative colitis, 5-ASA does not have any known anti-inflammatory effect on other organs or other colonic inflammatory diseases like diverticulitis. Moreover, the effect on experimental colitis in rodents is not convincing. 5-ASA seems to have a specific effect on the inflammation in ulcerative colitis. Research on the mechanism of its action may give information on the etiology of ulcerative colitis. 5-ASA is a first-line treatment th...Continue Reading

References

May 20, 1978·Lancet·H E LarsonS P Borriello
Dec 15, 1991·The New England Journal of Medicine·M J ThunC W Heath
Mar 1, 1987·Scandinavian Journal of Gastroenterology·U MonsénG Hellers
Aug 1, 1986·Postgraduate Medical Journal·S RaviE C Keat
Apr 1, 1986·The Journal of Infectious Diseases·G E BuckA R DiNuzzo
Apr 15, 1985·The Medical Journal of Australia·B J MarshallR J Glancy
Dec 14, 1974·British Medical Journal·D P Jewell, S C Truelove
May 1, 1981·Postgraduate Medical Journal·D S Rampton, G E Sladen
Sep 1, 1982·British Journal of Clinical Pharmacology·J B HoustonJ Walker
Jul 16, 1983·Lancet·J E Lennard-JonesC B Williams
Aug 1, 1983·British Journal of Clinical Pharmacology·M J DewJ Rhodes
Jun 1, 1996·Gastroenterology Clinics of North America·F M Giardiello
Mar 24, 1998·Diseases of the Colon and Rectum·P GionchettiM Campieri
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·T D WarnerJ R Vane
Nov 26, 1999·Alimentary Pharmacology & Therapeutics·P J BusG Griffioen
Jan 13, 2000·Alimentary Pharmacology & Therapeutics·G Corrigan, P E Stevens
Nov 21, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·R B Stein, S B Hanauer
Jun 6, 2002·Lancet·Stephen B HanauerUNKNOWN ACCENT I Study Group
Jan 25, 2003·The American Journal of Medicine·Sunanda KaneStephen Hanauer
Aug 14, 1954·British Medical Journal·S C TRUELOVE, L J WITTS
Oct 29, 1955·British Medical Journal·S C TRUELOVE, L J WITTS
Mar 27, 2004·Alimentary Pharmacology & Therapeutics·L BianconeF Pallone
Jul 6, 2004·Alimentary Pharmacology & Therapeutics·J R Bebb, B B Scott
May 4, 2005·Inflammatory Bowel Diseases·Cosimo PranteraMassimo Campieri
Dec 13, 2005·The New England Journal of Medicine·Paul RutgeertsJean Frédéric Colombel
Feb 14, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ken TakeuchiIngvar Bjarnason
Feb 14, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·William J SandbornBradley J Bloom

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Citations

Oct 27, 2015·Molecular Nutrition & Food Research·Elisa GinerRosa María Giner
Jan 24, 2017·Nature Microbiology·Jan-Ulrik DahlUrsula Jakob
May 11, 2018·Immunopharmacology and Immunotoxicology·Christian L HvasJørgen Agnholt
Oct 28, 2019·Current Drug Metabolism·Xiang-Lin Mei, Qing-Fan Zheng
Sep 5, 2017·Biological & Pharmaceutical Bulletin·Masateru MiyakeDaisuke Nakai
Jun 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiao-Bing HuangHuai-Rong Luo
May 17, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Zongqi HeYugen Chen
Nov 20, 2019·Journal of Clinical Medicine·Giovanni Clemente ActisDavide Giuseppe Ribaldone
Feb 27, 2021·Trends in Microbiology·Marvin Q Bowlin, Michael J Gray
Dec 12, 2018·International Immunopharmacology·Shulan QuYifu Yang
Jul 31, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Pedro M VelosoClarisse Nobre

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