5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity

Bioorganic & Medicinal Chemistry Letters
Kazutoshi WatanabeMasahiko Tanaka

Abstract

A series of 5-phenyl-substituted-N-alkyl-imidazolin-2-ones with potent radical-scavenging activity and lipid peroxidation inhibitory activity was synthesized. Many of the compounds showed memory-improving effect in animal models independent of the inhibitory activity on lipid peroxidation.

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Citations

Jan 26, 2013·Chemical Reviews·Bagher Eftekhari-SisAli Akbari
May 1, 2009·The Journal of Organic Chemistry·Baoguo ZhaoYian Shi
Apr 28, 2021·Bioorganic & Medicinal Chemistry·Emmanuel Ramsey Buabeng, Maged Henary
Aug 16, 2012·Organic Letters·Caroline Proulx, William D Lubell
Jun 7, 2011·The Journal of Organic Chemistry·Vsevolod A PeshkovErik V Van der Eycken

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