5-Arylethynyl-2'-deoxyuridines, compounds active against HSV-1

Organic & Biomolecular Chemistry
Mikhail V SkorobogatyiVladimir A Korshun

Abstract

Three new 5-arylethynyl-2'-deoxyuridines containing bulky aryls have been prepared and tested against HSV-1 in Vero cells. The introduction of a substituent in the phenyl group of an inactive compound, 5-phenylethynyl-2'-deoxyuridine, leads to the appearance of anti-HSV properties. The most active compounds are those containing a polycyclic aromatic hydrocarbon residue attached to the 5 position of 2'-deoxyuridine through a rigid triple bond.

References

Jul 18, 2002·Nature Reviews. Drug Discovery·Erik De Clercq
Mar 27, 2004·Nucleosides, Nucleotides & Nucleic Acids·Erik De Clercq
Oct 27, 2005·Nucleosides, Nucleotides & Nucleic Acids·A A PchelintsevaVladimir A Korshun

❮ Previous
Next ❯

Citations

Sep 9, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mireille R St VincentLuis M Schang
Feb 26, 2010·Nucleosides, Nucleotides & Nucleic Acids·Vineet Kumar, Sanjay V Malhotra
Nov 11, 2006·IDrugs : the Investigational Drugs Journal·Letitia Perry, Andrew Balfe
Sep 8, 2006·Organic Letters·Clemens Wagner, Hans-Achim Wagenknecht
Mar 6, 2007·Bioorganic & Medicinal Chemistry·Srinivasarao MeneniRoman Dembinski
Dec 21, 2017·Beilstein Journal of Organic Chemistry·Artur JabłońskiKonrad Kowalski
Sep 25, 2017·Nature Chemistry·Michael A CorselloNeil K Garg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.