5' Deiodinase activity in brain regions of adult rats: modifications in different situations of experimental hypothyroidism

Brain Research Bulletin
A Serrano-LozanoP Morata

Abstract

In the central nervous system, type II 5' deiodinase (5'D-II) is highly regulated, as judged by the dramatic changes in enzyme levels observed after abrupt alterations in thyroid status. In this work, the 5'-DII activity has been studied in different situations of experimental hypothyroidism (propylthiouracil, methimazole, thyroidectomy, and low iodine diet), in various brain regions (pituitary, cerebellum, brain stem, hypothalamus, cortex, and whole brain) in adult rats. Propylthiouracil and methimazole significantly increase the activity in all brain regions. These increases are higher in rats treated with methimazole. Thyroidectomy significantly increases the activity in cortex and pituitary. A low iodine diet significantly increases in all brain regions except in the hypothalamus. The concentration of triiodothyronine (T3) studied in the major brain regions remained unchanged. The results obtained show a compensatory mechanism in pituitary and other brain regions in order to maintain the T3 levels in brain tissue.

References

Dec 17, 1969·Biochimica Et Biophysica Acta·P R Walker, E Bailey
Sep 1, 1967·Canadian Journal of Microbiology·M W Zink
Aug 1, 1983·Journal of Nutritional Science and Vitaminology·M SuzukiA Yamane
Aug 1, 1984·The Journal of Clinical Endocrinology and Metabolism·M M Kaplan, E A Shaw
Aug 1, 1984·Endocrinology·M J ObregónG Morreale de Escobar
May 1, 1982·Endocrinology·P SantistebanG M De Escobar
Mar 1, 1983·Endocrinology·J L LeonardP R Larsen
Jan 1, 1981·Developmental Neuroscience·J Díez-GuerraF Valdivieso
Aug 31, 1981·Biochemical and Biophysical Research Communications·T J VisserP R Larsen
Sep 1, 1980·The Journal of Clinical Investigation·M M Kaplan, K A Yaskoski

❮ Previous
Next ❯

Citations

Jun 1, 1999·Nutrition Research Reviews·J R ArthurJ H Mitchell
Sep 1, 2005·Thyroid : Official Journal of the American Thyroid Association·Ronald M Lechan, Csaba Fekete
Jan 3, 2015·The Journal of Clinical Investigation·Joao Pedro Werneck de CastroAntonio C Bianco
Oct 28, 2017·Nature Reviews. Endocrinology·Jerome Clasadonte, Vincent Prevot
Jan 31, 2009·Endocrinology·Maria Izabel Chiamolera, Fredric E Wondisford
Jul 12, 2019·Frontiers in Endocrinology·Adair Rodríguez-RodríguezJean-Louis Charli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.