PMID: 8610636Apr 1, 1996Paper

5-Fluorouracil and alpha-interferon in hepatocellular carcinoma

American Journal of Clinical Oncology
K StuartM Huberman

Abstract

Hepatocellular carcinoma (HCC) is a major cause of mortality worldwide, and no effective systematic therapy currently exists. Recombinant alpha-interferon (IFN) has been suggested to have some antitumor efficacy in this illness, and synergism with 5-fluorouracil (5-FU) has been reported in several gastrointestinal malignancies. We therefore treated 10 patients with advanced HCC with combination therapy consisting of 5-FU 750/mg/m(2) weekly and IFN 9 X 10(6) units three times weekly. Toxicity was substantial in this cirrhotic population, and included mucositis as well as neurologic and hematologic side effects. There were no sustained antitumor responses. Median survival among this heavily pretreated population was 10 months. We were therefore unable to demonstrate any significant benefit to treatment with 5-FU and IFN in patients with HCC.

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Citations

May 8, 2004·The Cancer Journal·Mike Cusnir, Yehuda Z Patt
Nov 14, 2014·CNS Drugs·J van GaalenB P C van de Warrenburg
Aug 7, 2003·Cancer Investigation·Andrew X Zhu
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M LlovetJ Bruix
Sep 24, 2008·Alimentary Pharmacology & Therapeutics·M ChaparroR Moreno-Otero
Jun 16, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Anna K NowakMichael Findlay
Oct 19, 2006·Journal of Hepatology·Tim F GretenFirouzeh Korangy
Feb 24, 2001·Clinics in Liver Disease·A Aguayo, Y Z Patt
Aug 1, 1997·Clinics in Liver Disease·D G FarmerR W Busuttil
Oct 24, 2013·Translational Oncology·Takuji TorimuraMichio Sata
Mar 28, 2008·The Korean Journal of Hepatology·Chul Ju Han
Jun 2, 2001·Clinics in Liver Disease·A Aguayo, Y Z Patt

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