PMID: 2495166May 1, 1989Paper

5-Fluorouracil and UFT-sensitive gastric carcinoma has a high level of thymidylate synthase

Cancer
Y MaeharaK Sugimachi

Abstract

The authors examined the relationship between the level of thymidylate synthase (TS) and the sensitivity to 5-fluorouracil (5-FU) and UFT, a combined oral preparation of 1-(2-tetrahydrofuryl)-5-fluorouracil (tegafur) and uracil in a molar ratio of 1:4. For the studies we used the subrenal capsule (SRC) assay and 15 human gastric cancer tissues. The TS levels were assayed by the ligand-binding technique, using [6-3H]FdUMP. The relative variation of tumor size (delta TuS/TuS0) was calculated to be as follows: delta TuS/TuS0 = [(TuS6 - TuS0)/TuS0] x 100 (%), where TuS6 was the tumor size on day 6 and TuS0 on day 0. The chemosensitivity was considered to be positive when delta TuS/TuS0 in the treated group decreased to below -10%. Decrease in tumor size was marked in case of exposure to UFT (-19.8 +/- 13.0%) (mean +/- standard deviation), compared with that to 5-FU (-9.0 +/- 7.2%), with a statistically significant difference (P less than 0.001). The TS level varied from 1.7 to 30.8 pmol/g gastric cancer tissue and the mean was 7.1 +/- 7.2 pmol/g tissue. A correlation was noted between the TS level and decrease in size of the tumor exposed to 5-FU (r = -0.671) or UFT (r = -0.758): gastric cancer tissue with higher level of TS is mor...Continue Reading

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Citations

Mar 4, 2009·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Katrin KnopJean-Pierre Souchard
Nov 30, 2010·Therapeutic Delivery·Mohanad MossalamCarol S Lim
Nov 22, 2005·Pharmacogenomics·Richie Soong, Robert B Diasio
Jun 9, 2001·Seminars in Surgical Oncology·E SeregniE Bombardieri
Sep 5, 2006·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Wataru Ichikawa
Jan 1, 1993·Cancer Chemotherapy and Pharmacology·Y MaeharaK Sugimachi
Sep 16, 2019·International Journal of Clinical Oncology·Yoshihiko MaeharaMasaki Mori
Jan 1, 1993·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M MaetaN Kaibara
Dec 1, 1992·Journal of Surgical Oncology·Y MaeharaK Sugimachi
Jan 1, 1990·Seminars in Surgical Oncology·Y MaeharaK Sugimachi
Oct 13, 2006·Current Opinion in Gastroenterology·J C Yao, J A Ajani

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