PMID: 3383976Apr 1, 1988Paper

5-Fluorouracil, doxorubicin and mitomycin C (FAM) combination chemotherapy for metastatic adenocarcinoma of unknown primary

European Journal of Cancer & Clinical Oncology
A van der GaastG Stoter

Abstract

The prognosis of patients with adenocarcinoma of unknown primary (ACUP) is dismal. Various chemotherapy regimens have yielded disappointing response rates and survival. Based on a promising report of Goldberg et al. (J Clin Oncol 1986, 4, 395-399) we performed a phase II study with 5-fluorouracil, adriamycin and mitomycin C (FAM). Only three out of 22 evaluable patients achieved a partial response (14%) for a duration of 22, 30 and 74+ weeks. Median survival was 54+ weeks (range 35-74+ weeks) for responding patients and 33+ weeks (range 9-74+ weeks) for all treated patients. One patient (5%) developed mitomycin C induced hemolytic uremic syndrome. FAM cannot be recommended for routine use in patients with ACUP.

References

Jun 9, 1979·British Medical Journal·J F StewartR M Fox
Jul 4, 1977·JAMA : the Journal of the American Medical Association·D T Kiang, B J Kennedy
Jan 1, 1983·European Journal of Cancer & Clinical Oncology·H AndersonD Crowther

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Citations

Jan 1, 1991·Journal of Cancer Research and Clinical Oncology·J E Ultmann
Dec 13, 2005·Chemotherapy·K Jentsch-UllrichM Mohren
Apr 1, 1996·Hematology/oncology Clinics of North America·M RyttingN Jaffe
Dec 1, 1994·Cancer·C CanpolatN Jaffe

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