5-FU induced cardiotoxicity: case series and review of the literature

Cardio-Oncology
Cai YuanJason S Starr

Abstract

5-Fluorouracil (5-FU) is an antimetabolite chemotherapy used for a variety of solid tumors. It has the potential to cause a wide spectrum of cardiotoxicity, ranging from asymptomatic electrocardiographic changes to cardiomyopathy and subsequent cardiac failure. Main body of the abstract: We present two descriptive cases of new-onset severe cardiomyopathy induced by 5-FU followed by a review of the literature. Our case series emphasizes the importance of early recognition of this rare complication and prompt cessation of 5-FU, as cardiac dysfunction in this context is potentially reversible.

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Citations

Aug 11, 2020·Case Reports in Oncological Medicine·Mariam CharkvianiNur Un Nisa Nabil
Jan 25, 2021·International Journal of Colorectal Disease·Gaurav TalwarCagla Eskicioglu
Jan 14, 2021·World Journal of Clinical Oncology·Andrada Larisa DeacAnca Dana Buzoianu
Dec 17, 2020·Cancers·Kathryn J RuddyJoerg Herrmann
Sep 21, 2021·Frontiers in Cardiovascular Medicine·Andrea MontisciClaudio Napoli

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