Abstract
5-Heptadecylresorcinol (AR-C17) is a main component of the alkylresorcinols (ARs), and has been widely used as a biomarker for whole grain rye consumption. In the present study, the neuroprotective effect and potential defense mechanisms of AR-C17 against hydrogen peroxide (H2O2)-induced apoptosis and mitochondrial dysfunction were investigated in PC-12 cells. The results showed that AR-C17 treatment significantly suppressed oxidative damage to cells, and ROS-mediated cells apoptosis. Furthermore, AR-C17 improved multiple mitochondrial bioactivities, reducing mitochondrial ROS levels, maintaining the mitochondrial membrane potential and enhancing mitochondrial respiration, leading to an elevation in the cellular ATP production, maximal respiration and spare respiratory capacity. In addition, AR-C17 exposure dramatically increased the protein expression of SIRT3 and its downstream functional gene FOXO3a. The cytoprotective effect of AR-C17 was abolished by the SIRT3 inhibitor 3-TYP, which led to increased cell apoptosis. Taken together, our findings demonstrate that AR-C17 could be used as a potential nutraceutical in reducing neuronal oxidative damage.
References
May 13, 2003·The Proceedings of the Nutrition Society·Pauline Koh-Banerjee, Eric B Rimm
Jun 26, 2003·Journal of Agricultural and Food Chemistry·Alastair B RossPer Aman
Oct 24, 2006·The Journal of Nutrition·Rikard LandbergPer Aman
Feb 26, 2010·Journal of Alzheimer's Disease : JAD·Francesco SofiAlessandro Casini
Apr 2, 2013·Archives of Toxicology·Krishnendu SinhaParames C Sil
Apr 9, 2013·Food Chemistry·Matti MarklundC-Y Oliver Chen
Sep 21, 2013·Frontiers in Aging Neuroscience·Brad Kincaid, Ella Bossy-Wetzel
Nov 22, 2013·The Journal of Nutrition·Yingdong ZhuShengmin Sang
Feb 5, 2015·The Journal of Nutrition, Health & Aging·X ZhaoR Xiao
Feb 15, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Mio OzawaEric J Brunner
Apr 8, 2016·Neurochemical Research·Jing-Yi ZhangQiu-Min Qu
Jun 10, 2016·The American Journal of Clinical Nutrition·Izabela BiskupRikard Landberg
Nov 25, 2016·Neurochemical Research·Henryk JęśkoJoanna B Strosznajder
Feb 25, 2017·The American Journal of Chinese Medicine·Chang-Han ChenLi-Yen Shiu
Jul 13, 2017·Journal of Alzheimer's Disease : JAD·Vincenzo SolfrizziFrancesco Panza
Oct 5, 2017·Journal of Agricultural and Food Chemistry·Jie LiuLiangli Lucy Yu
Nov 4, 2017·Toxicology Letters·Hui WangTao Zhang
Nov 14, 2017·Aging Cell·Junghee LeeHoon Ryu
Jun 14, 2018·Aging and Disease·Meng ZhangQiu-Min Qu
Jul 5, 2018·Frontiers in Neuroscience·Jingwei ZhengJianmin Zhang
Aug 16, 2018·Journal of Agricultural and Food Chemistry·Jie LiuJing Wang
Sep 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Oksana SytarIryna Smetanska
Sep 19, 2018·Journal of Agricultural and Food Chemistry·Shengmin Sang
Apr 2, 2019·Nutritional Neuroscience·Waralee RuankhamKamonrat Phopin
May 3, 2019·Food & Function·Ziyuan WangJing Wang
Jun 30, 2019·Toxicology and Applied Pharmacology·Ru ZengShaoyu Zhou
Jul 7, 2019·Nutrients·Yiming HaoJing Wang
Sep 29, 2019·Aging·Lei YinBo Peng
Citations
Jan 22, 2021·Food Science & Nutrition·Jie LiuJing Wang
Nov 24, 2020·Pharmacology & Therapeutics·Zhibin LiangPamela Maher
Apr 27, 2021·Frontiers in Nutrition·Yiming HaoJing Wang
Jun 17, 2021·Journal of Food Biochemistry·Wei YangJing Wang
Apr 24, 2020·Journal of Agricultural and Food Chemistry·Jie LiuYanbei Wu
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wei YangJing Wang