5'-heterogeneity of the human excitatory amino acid transporter cDNA EAAT2 (GLT-1)

Neuroreport
C MünchT Meyer

Abstract

TWO novel transcripts of the human excitatory amino acid transporter EAAT2 (GLT-1) were cloned using PCR cloning techniques. Comparative sequence analysis of the 5'-untranslated region (UTR) of five EAAT2 transcripts led to the definition of five putative 5'-untranslated exons that are combined in a variable manner. Alternative splicing is a likely mechanism for the 5' complexity of the EAAT2 cDNA. The potential functional meaning of this finding such as differential expression of the EAAT2 transcripts in the central nervous system remains to be demonstrated.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Nov 1, 1990·Trends in Pharmacological Sciences·D Nicholls, D Attwell
Jan 1, 1990·Progress in Neurobiology·M Erecińska, I A Silver
Jan 1, 1989·Annual Review of Genetics·C W SmithB Nadal-Ginard
May 11, 1994·Biochimica Et Biophysica Acta·P ShashidharanA Plaitakis
Nov 1, 1995·Cancer Genetics and Cytogenetics·K KaltoftK Thestrup-Pedersen

❮ Previous
Next ❯

Citations

Sep 6, 2003·Experimental Neurology·Maciej FigielJürgen Engele
Oct 19, 2000·Brain Research. Molecular Brain Research·C MünchT Meyer
May 23, 2001·Progress in Neurobiology·N C Danbolt
Oct 10, 2002·The European Journal of Neuroscience·Karen SchlüterJürgen Engele
Aug 26, 1999·Drug Metabolism Reviews·A C Ludolph, C Münch
Oct 5, 2010·The International Journal of Biochemistry & Cell Biology·Aven Lee, David V Pow
Jan 22, 2005·Brain Research. Molecular Brain Research·Joanna Rozyczka, Jürgen Engele
Nov 20, 2014·European Journal of Human Genetics : EJHG·Alessia FiorentinoAndrew McQuillin
Aug 9, 2007·Molecular Psychiatry·T L Lauriat, L A McInnes
Aug 26, 1999·Journal of Neurochemistry·T P PalosB D Howard
Mar 10, 1999·The American Journal of Physiology·I ChoiW F Boron

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.