PMID: 7540261Feb 1, 1995Paper

5-HT, dopamine, norepinephrine, and related metabolites in brain of low alcohol drinking (LAD) rats shift after chronic intra-hippocampal infusion of harman

Neurochemical Research
A Adell, R D Myers

Abstract

Harman (1-methyl-beta-carboline) has been shown to induce preference for alcohol in the genetically bred, low alcohol drinking (LAD) rat. This study was undertaken in the LAD rat to determine whether monoamines and their metabolites in different regions of the brain are altered by harman infused chronically into the dorsal hippocampus. For this purpose, a cannula was implanted stereotaxically into the dorsal hippocampus. The cannula was attached to an osmotic minipump implanted subcutaneously within the intrascapular space. The pump was filled with either an artificial cerebrospinal fluid (CSF) vehicle or harman, which was delivered at a rate of 1.0 or 3.0 micrograms/h (i.e., 5.5 or 16.5 nmol/h, respectively) for a period of 14 days. Four days after surgery, a standard preference test for ethyl alcohol was given to the rats over 10 days in which concentrations were increased daily from 3%-30%. The higher concentration of harman infused into the hippocampus elevated the level of serotonin (5-HT), both ipsilateral and contralateral to the hippocampal site of infusion, as well as in the midbrain, frontal cortex, striatum and nucleus accumbens. Similarly, this treatment resulted in a rise in the levels of norepinephrine in the hipp...Continue Reading

References

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Citations

Apr 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·A Adell, R D Myers
May 14, 1998·Neuroscience and Biobehavioral Reviews·R D MyersM F Lankford
Oct 10, 2013·Neuroscience Letters·Mohammad NasehiMohammad-Reza Zarrindast
Dec 17, 2014·Brain Research·Haya Abu GhazalehAlan L Hudson
Oct 2, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Udo BonnetMartin Wiemann
Jul 30, 2005·Pharmacology, Biochemistry, and Behavior·Robert G PendletonRalph Hillman
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohammad NasehiMohammad-Reza Zarrindast

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