5-HT modifiers as a potential treatment of asthma

Trends in Pharmacological Sciences
I Cazzola, Maria Gabriella Matera

Abstract

Increased levels of free 5-HT have been shown to be present in the plasma of symptomatic asthmatic patients compared with levels in asymptomatic patients. In addition, free 5-HT has been shown to correlate positively with clinical status and negatively with pulmonary function. These findings suggest that 5-HT might play a role in the pathophysiology of acute asthma. Accordingly, modifiers of the 5-HT transmitter system such as compounds that affect the 5-HT transporter, prejunctional 5-HT receptors or postsynaptic 5-HT receptors might represent a novel treatment of asthma.

References

Dec 21, 2002·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Hildegard M SchullerBrian A Jull
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Brian J Jones, Thomas P Blackburn
Jun 6, 2000·Trends in Pharmacological Sciences·Mario Cazzola
Jun 6, 2000·Trends in Pharmacological Sciences·A G Ramage
Dec 29, 2000·Trends in Pharmacological Sciences·Faud Lechin
Apr 11, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Shannon R MurphyLaura S Van Winkle
Jul 31, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hiam Abdala-ValenciaJoan M Cook-Mills
Jun 23, 2009·American Journal of Respiratory Cell and Molecular Biology·Sandra M WellsAndrij Holian
Oct 19, 2013·American Journal of Respiratory Cell and Molecular Biology·Xiaoling GuYehuda Ben-Shahar
Dec 15, 2015·Respiratory Physiology & Neurobiology·G Córdoba-RodríguezPatricia Segura-Medina
Dec 2, 2010·European Journal of Pharmacology·Anna-Karin EkmanLars-Olaf Cardell
Mar 30, 2010·Pulmonary Pharmacology & Therapeutics·Sofia Fernandez-RodriguezEmma J Kidd
Apr 8, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·E Pretorius
Apr 13, 2007·The Journal of Investigative Dermatology·F SogaS Kishimoto
Oct 13, 2006·Clinical and Experimental Immunology·N KatohS Kishimoto
Aug 22, 2012·The Journal of Physiology·Carl PotenzieriBradley J Undem
Dec 10, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Patricia SeguraLuis M Montaño
Aug 21, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Shirin FarjadianMojtaba Farjam
Nov 28, 2001·Clinical Physiology·Faud Lechin
Oct 6, 2010·Journal of Ethnopharmacology·Deepti AhujaAjudhia N Kalia
Oct 18, 2001·Pulmonary Pharmacology & Therapeutics·P J Barnes
Dec 16, 2006·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Agapios SachinidisJurgen Hescheler
Apr 18, 2012·Respiration; International Review of Thoracic Diseases·Brian D MooreEdward S Schelegle
Dec 1, 2005·Nordic Journal of Psychiatry·Øyvind MelienOdd Brørs
Jul 13, 2016·Physiological Reports·Joshua D ChandlerDean P Jones
Aug 5, 2004·European Journal of Human Genetics : EJHG·Lauren A WeissMark Abney
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Albrecht Bergner, Michael J Sanderson
Aug 22, 2006·Journal of Enzyme Inhibition and Medicinal Chemistry·Amaury FarcePhilippe Chavatte
Mar 30, 2017·Frontiers in Cellular Neuroscience·Junhua Lv, Feng Liu
May 16, 2018·Scientific Reports·Maryam KeshavarzGabriela Krasteva-Christ
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stefen A BoehmeP Sriramarao
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nataliya M Kushnir-SukhovDean D Metcalfe
Jun 14, 2019·Frontiers in Immunology·Erika Méndez-Enríquez, Jenny Hallgren

Citations

Jul 1, 1985·Clinical Allergy·S Y SoS Kwan
Jan 1, 1988·European Journal of Clinical Pharmacology·D J StottS G Ball
Jan 1, 1988·Critical Care Medicine·D J Prezant, T K Aldrich
Jul 1, 1995·American Journal of Respiratory and Critical Care Medicine·T NagaseM S Ludwig
Jan 1, 1995·Allergy·Mario CazzolaF Rossi
Sep 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·F LechinA E Lechin
Feb 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T SatoS F Rabito
Jul 1, 1997·Naunyn-Schmiedeberg's Archives of Pharmacology·K M James, L J Bryan-Lluka
Nov 5, 1997·European Journal of Pharmacology·C C Gerhardt, H van Heerikhuizen
Apr 16, 1998·Psychosomatics·J W SmollerR L Kradin
Sep 24, 1998·Trends in Pharmacological Sciences·P R SaxenaC M Villalón
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·L J DupontG M Verleden

Related Concepts

Serotonin Effect
Serotonin
Receptors, Tryptamine
Anti-Asthmatic Agents
Asthma
Membrane Transport Proteins
Physiopathological
Acute Asthma
Status Asthmaticus
Pulmonary Function

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.