5-HT modulation by acute tryptophan depletion of human instrumental contingency judgements.

Psychopharmacology
Henry W ChaseT W Robbins

Abstract

The concept of 'depressive realism', that depression leads to more accurate perception of causal control, has been influential in the field of depression research, but remains controversial. Recent work testing contingency learning has suggested that contextual processing might determine realism-like effects. Serotonin (5-hydroxytryptamine, (5-HT)), which is implicated in the pathophysiology of depression, might also influence contextual processing. Using acute tryptophan depletion (ATD), we tested the hypothesis that dysfunctional serotoninergic neurotransmission influences contingency judgements in dysphoric subjects via an effect on contextual processing. We employed a novel contingency learning task to obtain separate measures (ratings) of the causal effect of participants' responses and efficacy of the background context over an outcome. Participants, without a history of depression, completed this task on and off ATD in a double-blind, placebo-controlled, within-subjects design. As with other work on contingency learning, the effects of ATD were related to baseline mood levels. Although no overall effects of ATD were observed, the subgroup of participants with low Beck depression inventory (BDI) scores showed reduced rati...Continue Reading

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Citations

May 22, 2013·PloS One·Rachel M MsetfiRobin A Murphy
Mar 26, 2011·Neuroscience and Biobehavioral Reviews·Geoffrey van der Plasse, Matthijs G P Feenstra
Nov 7, 2012·Journal of Personality·Nicola C Byrom, Robin A Murphy
Jan 9, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rebecca L BarlowJeffrey W Dalley
Oct 19, 2014·Psychopharmacology·Hanneke E M den OudenRoshan Cools
Mar 10, 2015·Frontiers in Psychology·Adam M Chekroud
Aug 12, 2017·Psychopharmacology·Sarah L MartinAnthony K P Jones

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Software Mentioned

Visual Basic
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