5-HT receptor subtypes involved in the anxiogenic-like action and associated Fos response of acute fluoxetine treatment in rats

Psychopharmacology
Peter Salchner, Nicolas Singewald

Abstract

We have recently reported that acute treatment with the selective serotonin reuptake inhibitor fluoxetine exacerbates escape responses to airjet and facilitates airjet-induced activation of locus coeruleus (LC) neurons. Here we aimed to identify the 5-HT receptor subtype(s) mediating the anxiogenic-like effects of acute fluoxetine in this paradigm and to study whether chronic fluoxetine treatment would alter these responses. The expression of the immediate early gene c-fos was used as a marker of neuronal activation. Acute fluoxetine increased the airjet-induced escape behaviour and Fos expression in the LC of saline-pretreated rats. Pretreatment with the 5-HT(2C/2B) antagonist SB 206553, but not with the 5-HT1A antagonist WAY 100635, the 5-HT1B antagonist SB 224289 or the 5-HT3 antagonist Y-25130 inhibited the fluoxetine-induced increase in escape behaviour and the associated elevated LC Fos response. The selective 5-HT2C agonist MK-212 mimicked the anxiogenic response of fluoxetine. Chronic treatment with fluoxetine abolished the anxiogenic-like effect and led to a normalization of the enhanced fluoxetine-induced Fos response to airjet. Taken together, the results indicate that the anxiogenic-like effect as well as the facili...Continue Reading

References

Apr 1, 1995·Pharmacology & Therapeutics·S L Handley
Jan 16, 1995·The Journal of Comparative Neurology·D E WrightL Jennes
Apr 1, 1994·Brain Research. Molecular Brain Research·M PompeianoG Mengod
May 1, 1994·Progress in Neuro-psychopharmacology & Biological Psychiatry·F JenckJ R Martin
May 1, 1993·The Journal of Pharmacy and Pharmacology·R CesanaF Borsini
Apr 1, 1996·British Journal of Pharmacology·G A KennettT P Blackburn
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y G Ni, R Miledi
Mar 1, 1997·The European Journal of Neuroscience·N SingewaldA Philippu
Apr 1, 1997·Neuropharmacology·G A KennettT P Blackburn
Jan 4, 1998·Pharmacology, Biochemistry, and Behavior·P O MoraF G Graeff
May 30, 1998·Journal of Neuroscience Methods·T SaitoT Nemoto
Aug 26, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·F JenckA M Van Delft
Oct 7, 1998·Progress in Neurobiology·N Singewald, A Philippu
May 27, 1999·Molecular and Chemical Neuropathology·K A Skau, C G Triplett
Aug 26, 1999·Neuropharmacology·N M Barnes, T Sharp
Jul 5, 2001·Physiology & Behavior·E J Van BockstaeleR J Valentino
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Brian J Jones, Thomas P Blackburn
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·James R MartinGuy A Higgins
Aug 31, 2002·Psychopharmacology·Franco BorsiniDonatella Marazziti
Oct 31, 2002·Human Psychopharmacology·Marie NaughtonBrian E. Leonard
Nov 20, 2002·Biological Psychiatry·Justine M KentJack M Gorman
Jan 16, 2003·Neuropharmacology·Peter Salchner, Nicolas Singewald
Jan 29, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Meera VaswaniSubramanyam Ramesh
Aug 21, 2003·Progress in Neurobiology·Mark J Millan
Dec 20, 2003·Current Drug Targets. CNS and Neurological Disorders·Martyn D Wood
Apr 20, 2004·Neuroreport·Tolga UzHari Manev
Dec 14, 2004·NeuroImage·Belinda J LiddellLeanne M Williams
Jan 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael T EnglanderClaudia Schmauss

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Citations

Dec 27, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Mark J Millan
Oct 3, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alain GobertMark J Millan
Aug 25, 2012·Expert Opinion on Investigational Drugs·Gaël QuesseveurBruno P Guiard
Jul 28, 2012·Behavioural Brain Research·Sarah AdamsLynda Uphouse
Sep 20, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Antonio Drago, Alessandro Serretti
Dec 24, 2014·Acta Physiologica Hungarica·M KolcsarM T Dogaru
May 24, 2011·Journal of Affective Disorders·Konstantinos N FountoulakisHagop Akiskal
Dec 17, 2009·The International Journal of Neuropsychopharmacology·Cedric MombereauJulie A Blendy
Sep 8, 2009·Journal of Neuroimmunology·María Guadalupe Reyes-García, Fernando García-Tamayo
Sep 20, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Andreas FrickTomas Furmark

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