PMID: 8968727Nov 1, 1996Paper

5-HT receptors in mammalian brain: receptor autoradiography and in situ hybridization studies of new ligands and newly identified receptors

The Histochemical Journal
G MengodJ M Palacios

Abstract

In recent years the family of mammalian serotonin receptors has grown to 14 different subtypes, characterized by pharmacological or molecular biological techniques. In parallel, new ligand molecules have been developed for their study. However, selective ligands are not yet available to study every one of them. In addition the degree of selectivity of ligands, hitherto regarded as specific for a particular receptor subtype has been called in question by their affinities for newly discovered receptors. Consequently, a re-evaluation of past ligand receptor autoradiography work is necessary in view of the redefined receptor profiles of these ligands, and the introduction of newly developed ligands. A further difficulty for the characterization of these receptors is the absence of selective antagonist ligands which, for some of the subtypes, have become available only recently. In an attempt to overcome these difficulties we have combined in situ hybridization histochemistry and receptor ligand autoradiography to study the regional and cellular localization of several serotonin receptors in the rodent brain. In addition, for some receptors, we have expanded these studies to primates, including humans. We have found that the distrib...Continue Reading

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Citations

Mar 30, 2004·Autonomic Neuroscience : Basic & Clinical·Mary M NiblockJames J Filiano
Mar 23, 2004·European Journal of Pharmacology·Peter B HedlundPascal Bonaventure
Jan 12, 1999·Neuroscience and Biobehavioral Reviews·N G SimonS Hu
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Mar 30, 2004·The Journal of Comparative Neurology·David S PatersonHannah C Kinney

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