PMID: 7517413Mar 1, 1994Paper

5-HT-related, anxiety- and/or aggression-driven depression

International Clinical Psychopharmacology
H M van Praag

Abstract

Mood lowering is considered to be the prime factor in the diagnosis of depression. However, it has been proposed that in a subset of cases of depression, the primary symptoms are anxiety and/or aggression. It has also been shown that these symptoms coincide with disturbance of 5-hydroxytryptamine (5-HT), which is frequently seen in depressed patients and has been suggested to be a vulnerability factor in the onset of depressive phases. If the concept of this proposed subset of depression--termed "5-HT-related, anxiety-and/or aggression-driven depression"--is accepted, this will lead to a review of the mode of diagnosis of depression and a reorientation of research into antidepressant drugs.

Citations

Jul 29, 2000·European Journal of Pharmacology·J A BouwknechtB Olivier
Mar 17, 2004·Journal of Affective Disorders·Alfonso Troisi, Alberto D'Argenio
Aug 10, 2005·Psychotherapy and Psychosomatics·Dietmar WinklerSiegfried Kasper
Jul 16, 2002·Journal of Affective Disorders·Jeanette B DijkstraAdriaan Honig
Apr 21, 2010·Psychological Reports·Michela Balsamo
Oct 28, 2011·Journal of Affective Disorders·Andrzej JakubczykMarcin Wojnar
Feb 18, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·O B Fasmer, K J Oedegaard
Mar 1, 1996·Acta Neuropsychiatrica·W M VerhoevenJ B Noten
Dec 1, 1995·Acta Neuropsychiatrica·S Tuinier, W M Verhoeven
Apr 17, 2019·Experimental and Therapeutic Medicine·You ZouShi-Ming Chen
Jun 1, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·H M Van Praag

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