PMID: 8967488May 1, 1996Paper

5-HT released by mucosal stimuli initiates peristalsis by activating 5-HT4/5-HT1p receptors on sensory CGRP neurons

The American Journal of Physiology
J R GriderJ G Jin

Abstract

The intestinal peristaltic reflex can be elicited by mucosal stimulation or circular muscle stretch. Muscle stretch activates extrinsic, whereas mucosal stimulation activates intrinsic calcitonin gene-related peptide (CGRP)-containing sensory neurons. The present study examined the role of 5-hydroxytryptamine (5-HT) in sensory transmission. A three-compartment preparation of rat colon was used that enables separate measurement of sensory transmitters and modulators. Mucosal stimuli (2-8 brush strokes) caused concurrent increase in 5-HT and CGRP release in proportion to the intensity of stimulation. Release of both 5-HT and CGRP occurred exclusively into the central compartment where the stimuli were applied. Exogenous 5-HT caused a concentration-dependent release of CGRP. Release of CGRP induced by exogenous 5-HT or mucosal stimulation was inhibited by selective 5-HT4 and 5-HT1p antagonists but was not affected by 5-HT1A, 5-HT2, and 5-HT3 antagonists. Ascending contraction and descending relaxation of circular muscle measured in the peripheral orad and caudad compartments, respectively, were also selectively inhibited by 5-HT4 and 5-HT1p antagonists added to the central but not peripheral compartments. In contrast, muscle stret...Continue Reading

Citations

Apr 10, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·J R Grider
Nov 14, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Henry C LinJin Hai Chen
Mar 11, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Henry C LinJin Hai Chen
Oct 15, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·John R Grider
Jun 21, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hiroshi TaniguchiToku Takahashi
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Jun 25, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·D PattonS Vanner
Sep 16, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·J R Grider, B E Piland
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Apr 7, 2007·The Nurse Practitioner·Margaret Heitkemper, Juvann Wolff
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Dec 20, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephan C BischoffMichael D Gershon
Feb 19, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Natalija MilkovaJi-Hong Chen
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Sep 2, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sarah A NajjarKristen M Smith-Edwards

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