PMID: 7516208Feb 1, 1994Paper

5-HT1-receptor-mediated vasoconstriction in bovine isolated pulmonary arteries: influences of vascular endothelium and tone

Pulmonary Pharmacology
M R MacLeanA G Templeton

Abstract

Vasoconstrictor responses to 5-hydroxytryptamine (5-HT) and the 5-HT1D receptor agonist sumatriptan were studied in isolated bovine pulmonary artery rings. The effects of the antagonists, ketanserin (5-HT2A-receptors) and methiothepin (5-HT1- and 5-HT2A-receptors) on these responses were determined. The influences of vascular tone and the effect of removal of the vascular endothelium and pretreatment with the inhibitor of nitric oxide synthase, N omega-nitro-L-arginine methylester, were also studied. In the absence of tone, in the majority of vessels, sumatriptan did not induce significant contractions. 5-HT-induced responses were concentration-dependent and ketanserin and methiothepin antagonized these in a competitive fashion. Removal of the endothelium or inclusion of L-NAME potentiated responses to sumatriptan. The sensitivity to sumatriptan was increased by L-NAME only in the presence of the endothelium whilst maximum responses to sumatriptan were potentiated in both unrubbed and rubbed vessels. Removal of the endothelium and/or inclusion of L-NAME had no significant effect on responses to 5-HT. U46619-induced tone markedly increased sumatriptan-induced responses which were competitively antagonized by methiothepin but wer...Continue Reading

Citations

Jun 1, 1996·Cephalalgia : an International Journal of Headache·H HenkesH C Diener
Mar 17, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·John Q Liu, Rodney J Folz
Sep 1, 2004·American Journal of Veterinary Research·Mireille MeylanAdrian Steiner
May 30, 2002·Biological & Pharmaceutical Bulletin·María VillazónMaría Isabel Loza
May 12, 2009·BMC Pulmonary Medicine·Daniel CronaJames West
Jan 16, 2004·The Journal of Pharmacology and Experimental Therapeutics·Anindya BhattacharyaMarlene L Cohen
Sep 1, 1996·British Journal of Pharmacology·M R MacLeanI Morecroft
May 2, 2003·Expert Opinion on Investigational Drugs·Sheila A Doggrell
Nov 9, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Anindya BhattacharyaMarlene L Cohen
Jan 13, 2001·British Journal of Pharmacology·A Elhusseiny, E Hamel
Feb 3, 2012·Physiological Reviews·J T SylvesterJeremy P T Ward

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