5-HT1A and 5-HT1B receptors differentially modulate rate and timing of auditory responses in the mouse inferior colliculus.

The European Journal of Neuroscience
Lissandra Castellan Baldan RamseyL M Hurley

Abstract

Serotonin (5-hydroxytryptamine; 5-HT) is a physiological signal that translates both internal and external information about behavioral context into changes in sensory processing through a diverse array of receptors. The details of this process, particularly how receptors interact to shape sensory encoding, are poorly understood. In the inferior colliculus, a midbrain auditory nucleus, 5-HT1A receptors have suppressive and 5-HT1B receptors have facilitatory effects on evoked responses of neurons. We explored how these two receptor classes interact by testing three hypotheses: that they (i) affect separate neuron populations; (ii) affect different response properties; or (iii) have different endogenous patterns of activation. The first two hypotheses were tested by iontophoretic application of 5-HT1A and 5-HT1B receptor agonists individually and together to neurons in vivo. 5-HT1A and 5-HT1B agonists affected overlapping populations of neurons. During co-application, 5-HT1A and 5-HT1B agonists influenced spike rate and frequency bandwidth additively, with each moderating the effect of the other. In contrast, although both agonists individually influenced latencies and interspike intervals, the 5-HT1A agonist dominated these meas...Continue Reading

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Citations

Jul 27, 2011·Behavioral Neuroscience·Ian C HallLaura M Hurley
Jan 29, 2013·Journal of Visualized Experiments : JoVE·Anna DondzilloAchim Klug
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Dec 22, 2015·Hearing Research·Melissa A Papesh, Laura M Hurley
Oct 7, 2017·Integrative and Comparative Biology·Christopher L Petersen, Laura M Hurley

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