Nov 1, 1996

5-HT1A and 5-HT2A receptor mRNAs and binding site densities are differentially altered in schizophrenia

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
P W J BurnetPaul J Harrison

Abstract

We have investigated 5-HT1A (serotonin1A) and 5-HT2A (serotonin2A) receptor mRNA abundance and binding site densities in various neocortical and hippocampal regions of schizophrenics and control subjects. Age, agonal state (brain pH), and post mortem interval were included where necessary as covariates in our analyses. In schizophrenics, 5-HT1A binding site densities, determined autoradiographically by [3H]8-hydroxy-2,3-(dipropylamino)-tetralin ([3H]8-OH-DPAT), were significantly increased (+23%) in the dorsolateral prefrontal cortex, with a similar trend in anterior cingulate gyrus. These increases were not accompanied by any change in 5-HT1A receptor mRNA. No differences between the groups in [3H]8-OH-DPAT binding or 5-HT1A receptor mRNA were seen in superior temporal gyrus, striate cortex, or hippocampus. 5-HT2A binding sites, determined by [3H]ketanserin, were decreased in the dorsolateral prefrontal cortex (-27%) and parahippocampal gyrus (-38%) of schizophrenics, with a similar trend in cingulate gyrus, but not in superior temporal gyrus or striate cortex. 5-HT2A receptor mRNA abundance was reduced in schizophrenics in the dorsolateral prefrontal (-49%), superior temporal (-48%), anterior cingulate (-63%) and striate (-63...Continue Reading

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Mentioned in this Paper

Antipsychotic Effect
Biochemical Pathway
Receptor, Serotonin,5-HT2A
Adrenal Cortex Diseases
Assay OF Haloperidol
Prefrontal Cortex
Imbalance
Schizophrenia
HTR2A wt Allele
Htr1a

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