5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
In-Jee YouSunmee Wee

Abstract

Cocaine addiction and depression are comorbid disorders. Although it is well recognized that 5-hydroxytryptamine (5-HT; serotonin) plays a central role in depression, our understanding of its role in addiction is notably lacking. The 5-HT system in the brain is carefully controlled by a combined process of regulating 5-HT neuron firing through 5-HT autoreceptors, neurotransmitter release, enzymatic degradation, and reuptake by transporters. This study tests the hypothesis that activation of 5-HT1A autoreceptors, which would lessen 5-HT neuron firing, contributes to cocaine-seeking behaviors. Using 5-HT neuron-specific reduction of 5-HT1A autoreceptor gene expression in mice, we demonstrate that 5-HT1A autoreceptors are necessary for cocaine conditioned place preference. In addition, using designer receptors exclusively activated by designer drugs (DREADDs) technology, we found that stimulation of the serotonergic dorsal raphe nucleus (DRN) afferents to the nucleus accumbens (NAc) abolishes cocaine reward and promotes antidepressive-like behaviors. Finally, using a rat model of compulsive-like cocaine self-administration, we found that inhibition of dorsal raphe 5-HT1A autoreceptors attenuates cocaine self-administration in rats...Continue Reading

References

Jan 1, 1992·Physiological Reviews·B L Jacobs, E C Azmitia
Jan 1, 1989·Psychopathology·D S RobinsonP Wickramaratne
Jan 1, 1993·Psychopharmacology·R Peltier, S Schenk
Sep 1, 1994·Progress in Neuro-psychopharmacology & Biological Psychiatry·D J Calcagnetti, M D Schechter
Jul 1, 1997·Pharmacology, Biochemistry, and Behavior·G F KoobF Weiss
Mar 25, 1998·Pharmacology, Biochemistry, and Behavior·S Herges, D A Taylor
Feb 3, 1999·Annals of the New York Academy of Sciences·P BlierC de Montigny
Dec 26, 2001·Journal of Neurochemistry·S MangiavacchiC Gambarana
Apr 3, 2002·Archives of General Psychiatry·Deborah HasinJean Endicott
Jun 11, 2002·Nature Neuroscience·Serge H AhmedAthina Markou
Feb 1, 2003·Biological Psychiatry·Pierre Blier, Nick M Ward
Oct 24, 2003·Journal of Neurophysiology·Sheryl G BeckLynn G Kirby
May 6, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karen K SzumlinskiPeter W Kalivas
Sep 12, 2006·Pharmacology, Biochemistry, and Behavior·Yukio AgoToshio Matsuda
Jan 5, 2007·The Journal of Pharmacology and Experimental Therapeutics·Sunmee WeeGeorge F Koob
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Blaine N ArmbrusterBryan L Roth
May 15, 2007·The American Journal of Drug and Alcohol Abuse·James PolingMehmet Sofuoglu
Jul 3, 2007·The Journal of Pharmacology and Experimental Therapeutics·Lori A Knackstedt, Peter W Kalivas
Jul 27, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul J FletcherGuy A Higgins
Sep 27, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Harinder AujlaFriedbert Weiss
Oct 9, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Sunmee WeeGeorge F Koob
Jul 10, 2008·The International Journal of Neuropsychopharmacology·Thibault RenoirLaurence Lanfumey
Jul 22, 2008·Neuropharmacology·Brice Le FrançoisPaul R Albert
Jul 26, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·George F Koob, Michel Le Moal

❮ Previous
Next ❯

Citations

Sep 30, 2016·Expert Review of Neurotherapeutics·Bas T H de VeenJudith R Homberg
Jan 26, 2017·Neuropharmacology·Matthew T ReillyGeorge F Koob
Jun 7, 2017·British Journal of Pharmacology·Linda D SimmlerRandy D Blakely
Dec 3, 2016·Journal of Psychopharmacology·Clinton E Canal, Kevin S Murnane
May 14, 2020·Journal of Neurophysiology·Tyler R SizemoreAndrew M Dacks
Jan 25, 2019·Cold Spring Harbor Symposia on Quantitative Biology·Anna M Klawonn, Robert C Malenka
Jan 17, 2017·Pharmacological Reports : PR·Grzegorz Dobrzanski, Małgorzata Kossut
Dec 18, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jessie MuirRosemary C Bagot
Nov 25, 2020·Molecular Biology Reports·Alec J DiVito, Robert F Leger
Dec 31, 2020·International Journal of Molecular Sciences·Ewa Galaj, Zheng-Xiong Xi
Jun 8, 2021·Frontiers in Pharmacology·Francisco NavarreteJorge Manzanares
Jun 10, 2020·Cold Spring Harbor Perspectives in Medicine·Louk J M J Vanderschuren, Serge H Ahmed

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.