5-HT1a Receptor Involvement in Temporal Memory and the Response to Temporal Ambiguity

Frontiers in Neuroscience
Zvi R ShapiroMatthew S Matell

Abstract

It has previously been demonstrated that rats trained on the peak-interval procedure to associate two different cues with two different fixed interval schedules will generate a scalar peak function at an intermediate time when presented with the compound cue. This response pattern has been interpreted as resulting from the simultaneous retrieval of different temporal memories, and a consequential averaging process to resolve the ambiguity. In the present set of studies, we investigated the role that serotonin 1a receptors play in this process. In Experiment 1, rats were trained on a peak-interval procedure to associate the interoceptive states induced by saline and the 5-HT1a agonist, 8-OH-DPAT, with a 5 s or 20 s fixed-interval schedule signaled by the same tone cue (counter-balanced). While peak functions following administration of saline were centered at the appropriate time (5 s or 20 s), peak functions following administration of the agonist were centered around 7 s, irrespective of the reinforced time during training, suggesting agonist-induced disruption in selective temporal memory retrieval, resulting in increased ambiguity regarding the appropriate time at which to respond. In Experiment 2, rats were trained in a pea...Continue Reading

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Citations

Feb 7, 2019·Frontiers in Neuroscience·Hong-Shu ChenJian-You Guo
Jul 14, 2021·Future Medicinal Chemistry·Agnieszka JankowskaGrażyna Chłoń-Rzepa

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