5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response

Nature Neuroscience
Benjamin A SamuelsRene Hen


Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressants, but the mechanisms by which they influence behavior are only partially resolved. Adult hippocampal neurogenesis is necessary for some of the responses to SSRIs, but it is not known whether mature dentate gyrus granule cells (DG GCs) also contribute. We deleted the serotonin 1A receptor (5HT1AR, a receptor required for the SSRI response) specifically from DG GCs and found that the effects of the SSRI fluoxetine on behavior and the hypothalamic-pituitary-adrenal (HPA) axis were abolished. By contrast, mice lacking 5HT1ARs only in young adult-born GCs (abGCs) showed normal fluoxetine responses. Notably, 5HT1AR-deficient mice engineered to express functional 5HT1ARs only in DG GCs responded to fluoxetine, indicating that 5HT1ARs in DG GCs are sufficient to mediate an antidepressant response. Taken together, these data indicate that both mature DG GCs and young abGCs must be engaged for an antidepressant response.


Jan 1, 1996·Depression and Anxiety·J M Gorman
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·S RambozR Hen
Feb 2, 1999·The British Journal of Psychiatry : the Journal of Mental Science·R McAskillD Taylor
Apr 5, 2002·Neuron·Eric J NestlerLisa M Monteggia
Apr 27, 2004·Nature·Christoph Schmidt-HieberJosef Bischofberger
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Lisa M MonteggiaEric J Nestler
Feb 8, 2005·Nature Biotechnology·Annalee W Nguyen, Patrick S Daugherty
Oct 1, 2005·Lab Animal·William T GoldeLuis L Rodriguez
Nov 24, 2006·PLoS Biology·Diego A LaplagneAlejandro F Schinder
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jennifer L Warner-Schmidt, Ronald S Duman
Jun 15, 2007·Nature Neuroscience·Theodoros TsetsenisCornelius Gross
Feb 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jing-Wen WangRené Hen
Jun 24, 2008·Behavioural Brain Research·Jason Hannon, Daniel Hoyer
Jul 22, 2008·Neuropharmacology·Brice Le FrançoisPaul R Albert
Jan 6, 2009·Annals of the New York Academy of Sciences·Ryan Jankord, James P Herman
Jan 7, 2009·Archives of General Psychiatry·Eric FakraAhmad R Hariri
May 27, 2009·Nature Reviews. Neuroscience·Yvonne M Ulrich-Lai, James P Herman
Jun 26, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joshua GreeneRonald S Duman
Feb 16, 2010·Neuron·Michael S Fanselow, Hong-Wei Dong
Feb 16, 2010·Neuron·Jesse W Richardson-JonesE David Leonardo
Mar 18, 2011·Molecular Brain·Katsunori KobayashiHidenori Suzuki
Apr 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jesse W Richardson-JonesE David Leonardo
May 4, 2011·Molecular Psychiatry·A SurgetC Belzung
Jun 11, 2011·Neuron·Alex DranovskyRene Hen
Mar 21, 2012·Hippocampus·Nesha S BurghardtAndré A Fenton
Jun 23, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mazen A KheirbekRené Hen
Jul 25, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kenji F TanakaRené Hen
Oct 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Emily G WaterhouseBaoji Xu
Jan 11, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maura BoldriniJ John Mann
Nov 30, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Indira Mendez-DavidRené Hen
Jan 15, 2014·Frontiers in Neural Circuits·Taruna IkrarAmar Sahay

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Mar 17, 2018·Frontiers in Pharmacology·Emmanuelle A D SchindlerDeepak C D'Souza
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