5-HT1B receptors, alpha2A/2C- and, to a lesser extent, alpha1-adrenoceptors mediate the external carotid vasoconstriction to ergotamine in vagosympathectomised dogs

Naunyn-Schmiedeberg's Archives of Pharmacology
Luis Felipe ValdiviaC M Villalón

Abstract

It has previously been suggested that ergotamine produces external carotid vasoconstriction in vagosympathectomised dogs via 5-HT1B/1D receptors and alpha2-adrenoceptors. The present study has reanalysed this suggestion by using more selective antagonists alone and in combination. Fifty-two anaesthetised dogs were prepared for ultrasonic measurements of external carotid blood flow. The animals were divided into thirteen groups (n=4 each) receiving an i.v. bolus injection of, either physiological saline (0.3 ml/kg; control), or the antagonists SB224289 (300 microg/kg; 5-HT1B), BRL15572 (300 microg/kg; 5-HT1D), rauwolscine (300 microg/kg; alpha2), SB224289 + BRL15572 (300 microg/kg each), SB224289 + rauwolscine (300 microg/kg each), BRL15572 + rauwolscine (300 microg/kg each), rauwolscine (300 microg/kg) + prazosin (100 microg/kg; alpha1), SB224289 (300 microg/kg) + prazosin (100 microg/kg), SB224289 (300 microg/kg) + rauwolscine (300 microg/kg) + prazosin (100 microg/kg), SB224289 (300 microg/kg) + prazosin (100 microg/kg) + BRL44408 (1,000 microg/kg; alpha2A), SB224289 (300 microg/kg) + prazosin (100 microg/kg)+ imiloxan (1,000 microg/kg; alpha2B), or SB224289 (300 microg/kg) + prazosin (100 microg/kg) + MK912 (300 microg/kg; a...Continue Reading

Citations

Aug 19, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Carlos M Villalón, David Centurión
Dec 11, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Tilo GörnemannHeinz H Pertz
Sep 10, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Luis E Cobos-PucDavid Centurión
May 12, 2006·Cephalalgia : an International Journal of Headache·U ArulmaniP R Saxena
Mar 21, 2007·Basic & Clinical Pharmacology & Toxicology·Suneet MehrotraAntoinette Maassen VandenBrink
Apr 14, 2016·European Journal of Pharmacology·Guadalupe C Vidal-CantúEnriqueta Muñoz-Islas
Oct 31, 2006·Pharmacology & Therapeutics·Saurabh GuptaAntoinette MaassenVanDenBrink
Mar 21, 2006·European Journal of Pharmacology·David CenturiónCarlos M Villalón
Dec 12, 2017·Expert Opinion on Drug Metabolism & Toxicology·Abimael González-HernándezCarlos M Villalón

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